# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA641988 | Binding | Binding affinity against Adenosine A2 receptor of striatal membrane using [3H]CGS-21680 | Cavia porcellus | 1 | ALA1126685 | assay format | Scientific Literature | |
2. | ALA640348 | Binding | Binding affinity against Adenosine A1 receptor of cerebral cortex using [3H]-CPX | Cavia porcellus | 1 | ALA1126685 | tissue-based format | Scientific Literature | |
3. | ALA653481 | Functional | Increased transcription of human calcitonin luciferase reporter gene at 30 uM | 16 | ALA1135752 | assay format | Scientific Literature | ||
4. | ALA685182 | Functional | Effective concentration required in vitro for tracheal muscle (from male Hartley guinea pigs) relaxation | Cavia porcellus | 1 | ALA1126685 | organism-based format | Scientific Literature | |
5. | ALA686050 | Functional | In vitro guinea pig heart stimulation (right atrium) | Cavia porcellus | 1 | ALA1126685 | organism-based format | Scientific Literature | |
6. | ALA696913 | Functional | Ability to increase Human calcitonin secretion | 16 | ALA1135752 | assay format | Scientific Literature | ||
7. | ALA693335 | Functional | Calcitonin (CT) secretion/RIA assay to measure the ability of compound to increase cellular levels and secretion of human CT. | Homo sapiens | 34 | ALA1132986 | cell-based format | Scientific Literature | |
8. | ALA696757 | Functional | CT-luci reporter gene assay to measure the ability to increase transcription of a luciferase receptor gene linked to the human CT gene. | Homo sapiens | 22 | ALA1132986 | cell-based format | Scientific Literature | |
9. | ALA824110 | Binding | Inhibition of cAMP-phosphodiesterase (PDE) from trachealis muscle homogenate supernatant | Cavia porcellus | 1 | ALA1126685 | tissue-based format | Scientific Literature | |
10. | ALA823443 | Functional | Positive chronotropic effect, 15% increase in heart rate of male Hartley guinea pigs on intraduodenal administration (mean of 3-5 animals) | Cavia porcellus | 1 | ALA1126685 | organism-based format | Scientific Literature | |
11. | ALA822017 | Functional | Bronchodilatory effect, 50% inhibition of spasmogen-induced response in male Hartley guinea pigs on intraduodenal administration | Cavia porcellus | 1 | ALA1126685 | organism-based format | Scientific Literature | |
12. | ALA849589 | Functional | Bronchoselectivity expressed as ratio of stimulatory activity in the right atrium (EC15) to relaxant activity in the tracheal muscle (EC50) | 1 | ALA1126685 | tissue-based format | Scientific Literature | ||
13. | ALA840643 | Functional | Bronchoselectivity, ratio of positive chronotropic action (ED15) to bronchodilator action (ED50) | 1 | ALA1126685 | assay format | Scientific Literature | ||
14. | ALA765683 | Binding | Inhibition of phosphodiesterase 4 (PDE4) | Homo sapiens | 3 | ALA1135752 | protein format | Scientific Literature | |
15. | ALA768606 | Binding | Percent Rolipram activity of a standard U937 cell phosphodiesterase 4 (PDE4) enzyme assay at 30 uM of compound | 16 | ALA1135752 | cell-based format | Scientific Literature | ||
16. | ALA810425 | Functional | Emetic effect in shrews at 30 mg/kg peroral dose, 3 of 3 animals affected | Suncus murinus | 1 | ALA1130176 | organism-based format | Scientific Literature | |
17. | ALA800813 | Functional | The compound was tested for its bone protection activity at 30 mg/kg/day by intra peritoneal administration. | Rattus norvegicus | 9 | ALA1132986 | organism-based format | Scientific Literature | |
18. | ALA757135 | Binding | Concentration at which 50% of the activity of the Phosphodiesterase 4 from Human U937 cells is inhibited | 8 | ALA1132986 | cell-based format | Scientific Literature | ||
19. | ALA757137 | Binding | Percent rolipram activity at 30 uM (PDE 30 assay) | Homo sapiens | 1 | ALA1132986 | protein format | Scientific Literature |