| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4812131 | F | Antitrypanosomal activity against nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC-5 SV2 cells assessed as inhibition of parasite growth measured after 7 days by spectrophotometric analysis | Trypanosoma cruzi | 80 | organism-based format | Scientific Literature | ||
| 2. | ALA4812132 | A | Cytotoxicity against human MRC-5 SV2 cells assessed as reduction in cell growth measured after 3 days by resazurin dye based fluorometric analysis | Homo sapiens | 79 | cell-based format | Scientific Literature | ||
| 3. | ALA4812133 | T | Selectivity index, ratio of CC50 for human MRC-5 SV2 cells to IC50 for antitrypanosomal activity against nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC-5 SV2 cells | 55 | cell-based format | Scientific Literature | |||
| 4. | ALA4812134 | F | Antileishmanial activity against amastigote form of Leishmania infantum MHOM/MA(BE)/67 infected in Swiss mouse peritoneal macrophages assessed as reduction in parasite growth treated at 2 hrs post-infection and measured after 5 days by Giemsa staining based microscopic analysis | Leishmania infantum | 80 | organism-based format | Scientific Literature | ||
| 5. | ALA4812135 | A | Cytotoxicity against Swiss mouse peritoneal macrophages assessed as cell detachment, lysis and granulation measured after 5 days by microscopic analysis | Mus musculus | 79 | cell-based format | Scientific Literature | ||
| 6. | ALA4812137 | A | Metabolic stability of the compound in mouse liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining at 5 uM measured after 15 mins in presence of NADPH by UPLC-MS analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 7. | ALA4812138 | A | Metabolic stability of the compound in mouse liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining at 5 uM measured after 30 mins in presence of NADPH by UPLC-MS analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 8. | ALA4812139 | A | Metabolic stability of the compound in mouse liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining at 5 uM measured after 60 mins in presence of NADPH by UPLC-MS analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 9. | ALA4812140 | A | Metabolic stability of the compound in human liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining at 5 uM measured after 15 mins in presence of NADPH by UPLC-MS analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 10. | ALA4812141 | A | Metabolic stability of the compound in human liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining at 5 uM measured after 30 mins in presence of NADPH by UPLC-MS analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 11. | ALA4812142 | A | Metabolic stability of the compound in human liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining at 5 uM measured after 60 mins in presence of NADPH by UPLC-MS analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 12. | ALA4812143 | A | Metabolic stability of the compound in mouse liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured after 15 mins in presence of UDPGA by UPLC-MS analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 13. | ALA4812144 | A | Metabolic stability of the compound in mouse liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured after 30 mins in presence of UDPGA by UPLC-MS analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 14. | ALA4812145 | A | Metabolic stability of the compound in mouse liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured after 60 mins in presence of UDPGA by UPLC-MS analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 15. | ALA4812146 | A | Metabolic stability of the compound in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured after 15 mins in presence of UDPGA by UPLC-MS analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 16. | ALA4812147 | A | Metabolic stability of the compound in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured after 30 mins in presence of UDPGA by UPLC-MS analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 17. | ALA4812148 | A | Metabolic stability of the compound in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured after 60 mins in presence of UDPGA by UPLC-MS analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 18. | ALA4812149 | F | Antitrypanosomal activity against Trypanosoma cruzi strain Y bloodstream trypomastigotes infected in Swiss Webster mouse assessed as reduction in parasitemia at 25 mg/kg, po bid for 5 days treatment started at 6 days post-infection and measured at 8 days post-infection by light microscopic analysis | Trypanosoma cruzi | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4812151 | F | Antitrypanosomal activity against Trypanosoma cruzi strain Y bloodstream trypomastigotes infected in Swiss Webster mouse assessed as reduction in parasitemia at 0.25 to 2.5 mg/kg, po bid for 5 days treatment started at 6 days post-infection by light microscopic analysis | Trypanosoma cruzi | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4812152 | F | Antitrypanosomal activity against Trypanosoma cruzi strain Y bloodstream trypomastigotes infected in Swiss Webster mouse assessed as reduction in parasitemia at 2.5 mg/kg, po bid for 5 days treatment started at 6 days post-infection in presence of 10 mg/kg, po Benznidazole by light microscopic analysis | Trypanosoma cruzi | 1 | organism-based format | Scientific Literature |
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