| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4839715 | Functional | Anti-synaptotoxic activity against mouse Neuro-2a cells assessed as inhibition of amyloid beta (1 to 42)-induced cytotoxicity by MTT-based Trafficking assay | Mus musculus | 8 | ALA4837254 | cell-based format | Scientific Literature | |
| 2. | ALA4839716 | Binding | Binding affinity to Sigma 2-receptor (unknown origin) | Homo sapiens | 8 | ALA4837254 | single protein format | Scientific Literature | |
| 3. | ALA4839717 | ADME | Half life in mouse liver microsomes | Mus musculus | 8 | ALA4837254 | microsome format | Scientific Literature | |
| 4. | ALA4839718 | Binding | Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assay | Homo sapiens | 7 | ALA4837254 | cell-based format | Scientific Literature | |
| 5. | ALA4839719 | ADME | Ratio of AUC in Brain to AUC in plasma | Not specified | 2 | ALA4837254 | cell-free format | Scientific Literature | |
| 6. | ALA4839720 | ADME | Ratio of drug level in brain to plasma measured after 24 hrs | Not specified | 4 | ALA4837254 | cell-free format | Scientific Literature | |
| 7. | ALA4839721 | ADME | Unbound brain-to-plasma concentration ratio measured after 24 hrs | Not specified | 1 | ALA4837254 | cell-free format | Scientific Literature | |
| 8. | ALA4839722 | ADME | Free drug level in brain | Not specified | 1 | ALA4837254 | tissue-based format | Scientific Literature | |
| 9. | ALA4839723 | ADME | Free drug level in plasma | Not specified | 1 | ALA4837254 | cell-free format | Scientific Literature | |
| 10. | ALA4839724 | ADME | Efflux ratio of apparent permeability from basolateral to apical membrane over apical to basolateral membrane in human Caco2 cells | Homo sapiens | 1 | ALA4837254 | cell-based format | Scientific Literature | |
| 11. | ALA4839725 | Functional | Prevention of vesicular membrane trafficking in Sprague-Dawley rat neurons assessed as inhibition of amyloid beta oligomer binding to nuclear receptor at 10 uM pretreated with compounds followed by amyloid beta oligomer challenge and measured after 1 hr by ELISA relative to control | Rattus norvegicus | 1 | ALA4837254 | tissue-based format | Scientific Literature | |
| 12. | ALA4839726 | Functional | Reversal of amyloid beta oligomer-induced vesicular membrane trafficking in Sprague-Dawley rat neurons at 1 uM pretreated with amyloid beta oligomer for 1 hr followed by compound treatment by ELISA relative to control | Rattus norvegicus | 1 | ALA4837254 | tissue-based format | Scientific Literature | |
| 13. | ALA4839727 | Functional | Prevention of vesicular membrane trafficking in Sprague-Dawley rat neurons assessed as inhibition of amyloid beta oligomer binding to nuclear receptor pretreated with compounds followed by amyloid beta oligomer challenge and measured after 1 hr by ELISA | Rattus norvegicus | 1 | ALA4837254 | tissue-based format | Scientific Literature | |
| 14. | ALA4839728 | Functional | Reversal of amyloid beta oligomer-induced vesicular membrane trafficking in Sprague-Dawley rat neurons pretreated with amyloid beta oligomer for 1 hr followed by compound treatment by ELISA | Rattus norvegicus | 1 | ALA4837254 | tissue-based format | Scientific Literature | |
| 15. | ALA4839729 | ADME | Cognitive enhancing effect in non-transgenic mouse assessed as swimming length measured after 1 day by Morris Water maze method (Rvb = 3791 +/-150 cm) | Mus musculus | 1 | ALA4837254 | assay format | Scientific Literature | |
| 16. | ALA4839730 | ADME | Cognitive enhancing effect in non-transgenic mouse assessed as swimming length measured after 2 day by Morris Water maze method (Rvb = 2666 +/-294 cm) | Mus musculus | 1 | ALA4837254 | assay format | Scientific Literature | |
| 17. | ALA4839731 | ADME | Cognitive enhancing effect in non-transgenic mouse assessed as swimming length measured after 3 days by Morris Water maze method (Rvb = 2173 +/-213 cm) | Mus musculus | 1 | ALA4837254 | assay format | Scientific Literature | |
| 18. | ALA4839732 | ADME | Cognitive enhancing effect in non-transgenic mouse assessed as swimming length measured after 4 days by Morris Water maze method (Rvb = 1797 +/-219 cm) | Mus musculus | 1 | ALA4837254 | assay format | Scientific Literature | |
| 19. | ALA4839733 | ADME | Cognitive enhancing effect in transgenic hAPP Swe/Ldn mouse assessed as swimming length measured after 1 day by Morris Water maze method (Rvb = 3518 +/-138 cm) | Mus musculus | 1 | ALA4837254 | assay format | Scientific Literature | |
| 20. | ALA4839734 | ADME | Cognitive enhancing effect in transgenic hAPP Swe/Ldn mouse assessed as swimming length measured after 2 day by Morris Water maze method (Rvb = 3252 +/-329 cm) | Mus musculus | 1 | ALA4837254 | assay format | Scientific Literature |
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