# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4826172 | Functional | Antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi Y infected in LLC-MK2 cells assessed as parasite growth inhibition by resazurin assay | Trypanosoma cruzi | 4 | ALA4825666 | organism-based format | Scientific Literature | |
2. | ALA4826173 | ADME | Cytotoxicity against mouse NCTC clone 929 cells assessed as reduction in cell viability after 48 hrs by MTT assay | Mus musculus | 4 | ALA4825666 | cell-based format | Scientific Literature | |
3. | ALA4826174 | Toxicity | Selectivity index, ratio of CC50 for cytotoxicity against mouse NCTC clone 929 cells to IC50 for trypomastigote forms of Trypanosoma cruzi Y infected in LLC-MK2 cells | 4 | ALA4825666 | cell-based format | Scientific Literature | ||
4. | ALA4826175 | Binding | Induction of cell membrane permeability in trypomastigote forms of Trypanosoma Cruzi Y at IC50 measured after 120 mins by SYSTOX Green assay | Trypanosoma cruzi | 2 | ALA4825666 | subcellular format | Scientific Literature | |
5. | ALA4826176 | Binding | Induction of cell membrane permeability in trypomastigote forms of Trypanosoma Cruzi Y at IC50 measured after 80 mins by SYSTOX Green assay | Trypanosoma cruzi | 2 | ALA4825666 | subcellular format | Scientific Literature | |
6. | ALA4826177 | Binding | Induction of acidocalcisome alkalinization in trypomastigotes form of Trypanosoma cruzi Y assessed as upregulation of Ca2+ level at IC50 using acridine orange measured after 60 min by fluorescent based assay | Trypanosoma cruzi | 2 | ALA4825666 | assay format | Scientific Literature | |
7. | ALA4826178 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Y assessed as increase in calcium level at IC50 measured upto 160 min by Fluo-4 AM probe-based spectrofluorimetric method | Trypanosoma cruzi | 2 | ALA4825666 | organism-based format | Scientific Literature | |
8. | ALA4826179 | Functional | Induction of mitochondrial membrane depolarization in trypomastigote forms of Trypanosoma cruzi Y at IC50 measured after 2 hrs by JC-1 staining based flow cytometry | Trypanosoma cruzi | 2 | ALA4825666 | organism-based format | Scientific Literature | |
9. | ALA4826180 | Functional | Antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi Y assessed as increase in ATP levels at IC50 incubated for 1 hrs by microplate reader method | Trypanosoma cruzi | 2 | ALA4825666 | organism-based format | Scientific Literature | |
10. | ALA4826181 | Functional | Antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi Y assessed as increase in ATP levels at IC50 incubated for 2 hrs by microplate reader method | Trypanosoma cruzi | 1 | ALA4825666 | organism-based format | Scientific Literature | |
11. | ALA4826182 | Functional | Induction of ROS generation in trypomastigote forms of Trypanosoma cruzi Y assessed as effect on reactive oxygen species level at IC50 for 2 hrs by fluorimetric microplate reader method | Trypanosoma cruzi | 2 | ALA4825666 | organism-based format | Scientific Literature | |
12. | ALA4826183 | Binding | Induction of plasma membrane depolarization in trypomastigote forms of Trypanosoma cruzi Y at IC50 measured after 2 hrs by DiSBAC2(3)-probe based assay | Trypanosoma cruzi | 3 | ALA4825666 | cell membrane format | Scientific Literature | |
13. | ALA4826184 | ADME | Substrate activity at P-gp (unknown origin) | Homo sapiens | 3 | ALA4825666 | single protein format | Scientific Literature | |
14. | ALA4826185 | ADME | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 3 | ALA4825666 | single protein format | Scientific Literature | |
15. | ALA4826186 | ADME | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 3 | ALA4825666 | single protein format | Scientific Literature | |
16. | ALA4826187 | ADME | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 3 | ALA4825666 | single protein format | Scientific Literature | |
17. | ALA4826188 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 3 | ALA4825666 | single protein format | Scientific Literature | |
18. | ALA4826189 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 3 | ALA4825666 | single protein format | Scientific Literature |