| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4840932 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as early apoptotic cells at 20 uM measured after 72 hrs by annexinV-FITC/propidium iodide staining based flow cytometry (Rvb = 5.3 %) | Homo sapiens | 1 | ALA4840323 | cell-based format | Scientific Literature | |
| 2. | ALA4840933 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as late apoptotic cells at 20 uM measured after 72 hrs by annexinV-FITC/propidium iodide staining based flow cytometry (Rvb = 8.8 %) | Homo sapiens | 1 | ALA4840323 | cell-based format | Scientific Literature | |
| 3. | ALA4840934 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as early apoptotic cells at 40 uM measured after 72 hrs by annexinV-FITC/propidium iodide staining based flow cytometry (Rvb = 5.3 %) | Homo sapiens | 1 | ALA4840323 | cell-based format | Scientific Literature | |
| 4. | ALA4840935 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as late apoptotic cells at 40 uM measured after 72 hrs by annexinV-FITC/propidium iodide staining based flow cytometry (Rvb = 8.8 %) | Homo sapiens | 1 | ALA4840323 | cell-based format | Scientific Literature | |
| 5. | ALA4840936 | B | Inhibition of C-terminal 6-His-tagged beta-catenin (1 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)-N-terminal biotinylated human BCL9 (350 to 375 residues) protein-protein interaction incubated for 1 hr by Alphascreen assay | Homo sapiens | 22 | ALA4840323 | assay format | Scientific Literature | |
| 6. | ALA4840937 | B | Competitive inhibition of C-terminal 6-His-tagged beta-catenin (1 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)-interaction with N-terminal biotinylated immobilized human BCL9 (350 to 375 residues) by SPR assay | Homo sapiens | 1 | ALA4840323 | assay format | Scientific Literature | |
| 7. | ALA4840939 | B | Inhibition of C-terminal 6-His-tagged beta-catenin R1C domain (138 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)-N-terminal biotinylated human BCL9 (350 to 375 residues) protein-protein interaction incubated for 1 hr by Alphascreen assay | Homo sapiens | 1 | ALA4840323 | assay format | Scientific Literature | |
| 8. | ALA4840940 | B | Inhibition of C-terminal 6-His-tagged beta-catenin (1 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)-N-terminal biotinylated human E-cadherin (824 to 877 residues) protein-protein interaction incubated for 1 hr by Alphascreen assay | Homo sapiens | 1 | ALA4840323 | assay format | Scientific Literature | |
| 9. | ALA4840941 | B | Ratio of Ki for inhibition of C-terminal 6-His-tagged beta-catenin R1C domain (138 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)-N-terminal biotinylated human BCL9 (350 to 375 residues) protein-protein interaction incubated for 1 hr by Alphascreen assay to Ki for inhibition of C-terminal 6-His-tagged beta-catenin (1 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)-N-terminal biotinylated human BCL9 (350 to 375 residues) protein-protein interaction incubated for 1 hr by Alphascreen assay | Homo sapiens | 1 | ALA4840323 | assay format | Scientific Literature | |
| 10. | ALA4840942 | B | Selectivity ratio of Ki for inhibition of C-terminal 6-His-tagged beta-catenin (1 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)-N-terminal biotinylated human E-cadherin (824 to 877 residues) protein-protein interaction incubated for 1 hr by Alphascreen assay to Ki for inhibition of C-terminal 6-His-tagged beta-catenin (1 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)-N-terminal biotinylated human BCL9 (350 to 375 residues) protein-protein interaction incubated for 1 hr by Alphascreen assay | Homo sapiens | 1 | ALA4840323 | assay format | Scientific Literature | |
| 11. | ALA4840943 | B | Inhibition of beta-catenin interaction with BCL9 in human HCT-116 cells measured after 24 hrs by co-immunoprecipitation assay | Homo sapiens | 1 | ALA4840323 | cell-based format | Scientific Literature | |
| 12. | ALA4840944 | B | Inhibition of beta-catenin interaction with E-cadherin in human HCT-116 cells at up to 40 uM measured after 24 hrs by co-immunoprecipitation assay | Homo sapiens | 1 | ALA4840323 | cell-based format | Scientific Literature | |
| 13. | ALA4840945 | B | Inhibition of beta-catenin interaction with PYGO2 in human HCT-116 cells at up to 40 uM measured after 24 hrs by co-immunoprecipitation assay | Homo sapiens | 1 | ALA4840323 | cell-based format | Scientific Literature | |
| 14. | ALA4840946 | B | Inhibition of BCL9 interaction with PYGO2 in human HCT-116 cells at up to 40 uM measured after 24 hrs by co-immunoprecipitation assay | Homo sapiens | 1 | ALA4840323 | cell-based format | Scientific Literature | |
| 15. | ALA4840947 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTS assay | Homo sapiens | 3 | ALA4840323 | cell-based format | Scientific Literature | |
| 16. | ALA4840948 | F | Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition measured after 72 hrs by MTS assay | Homo sapiens | 3 | ALA4840323 | cell-based format | Scientific Literature | |
| 17. | ALA4840949 | F | Antiproliferative activity against human SW480 cells assessed as cell growth inhibition measured after 72 hrs by MTS assay | Homo sapiens | 3 | ALA4840323 | cell-based format | Scientific Literature | |
| 18. | ALA4840950 | F | Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 72 hrs by MTS assay | Homo sapiens | 3 | ALA4840323 | cell-based format | Scientific Literature | |
| 19. | ALA4840951 | A | Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition measured after 72 hrs by MTS assay | Homo sapiens | 3 | ALA4840323 | cell-based format | Scientific Literature | |
| 20. | ALA4840952 | F | Antiproliferative activity against human MDA-MB-231 cells harboring empty pcDNA3.1 vector at 20 uM measured after 72 hrs by MTS assay | Homo sapiens | 1 | ALA4840323 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!