# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4821184 | B | Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response incubated for 5 mins by two electrode voltage-clamp assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
2. | ALA4821188 | B | Antagonist activity at human alpha9/alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 30 uM incubated for 5 mins by two electrode voltage-clamp assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
3. | ALA4821189 | B | Antagonist activity at human alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 30 uM incubated for 5 mins by two electrode voltage-clamp assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4821190 | B | Agonist activity at human GABAB expressed in HEK293T cells co-transfected with human CaV2.2-alpha1B channel assessed as inhibition of CaV2.2-mediated Ba2+ peak-current amplitude at 100 nM at -80 to 10 mV holding potential after 72 hrs by whole cell patch clamp assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
5. | ALA4821191 | B | Agonist activity at human GABAB expressed in HEK293T cells co-transfected with human CaV2.2-alpha2delta1 channel assessed as inhibition of CaV2.2-mediated Ba2+ peak-current amplitude at 100 nM at -80 to 10 mV holding potential after 72 hrs by whole cell patch clamp assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
6. | ALA4821192 | B | Agonist activity at human GABAB expressed in HEK293T cells co-transfected with human CaV2.2-beta3 channel assessed as inhibition of CaV2.2-mediated Ba2+ peak-current amplitude at 100 nM at -80 to 10 mV holding potential after 72 hrs by whole cell patch clamp assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
7. | ALA4821193 | B | Agonist activity at human GABAB expressed in HEK293T cells co-transfected with human CaV2.2 channel assessed as inhibition of CaV2.2-mediated Ba2+ peak-current amplitude at -80 to 10 mV holding potential after 72 hrs by whole cell patch clamp assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4821195 | F | Antiallodynic activity in Sprague-Dawley rat model of neuropathic mechanical allodynia assessed as increase in paw withdrawal threshold administered intramuscularly measured at 1 to 24 hrs post last dose by von Frey test | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
9. | ALA4821196 | F | Antiallodynic activity in Sprague-Dawley rat model of neuropathic mechanical allodynia assessed as increase in paw withdrawal threshold at 0.1 mg/kg, IM measured at 1 hr post last dose by von Frey test | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
10. | ALA4821197 | F | Antiallodynic activity in Sprague-Dawley rat model of neuropathic mechanical allodynia assessed as increase in paw withdrawal threshold at 0.1 mg/kg, IM measured at 2 hr post last dose by von Frey test | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
11. | ALA4821198 | F | Antiallodynic activity in Sprague-Dawley rat model of neuropathic mechanical allodynia assessed as increase in paw withdrawal threshold at 0.1 mg/kg, IM measured at 4 hr post last dose by von Frey test | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
12. | ALA4821199 | F | Antiallodynic activity in Sprague-Dawley rat model of neuropathic mechanical allodynia assessed as increase in paw withdrawal threshold at 0.1 mg/kg, IM measured at 6 hr post last dose by von Frey test | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
13. | ALA4821200 | F | Antiallodynic activity in Sprague-Dawley rat model of neuropathic mechanical allodynia assessed as increase in paw withdrawal threshold at 0.1 mg/kg, IM measured at 24 hrs post last dose by von Frey test | Rattus norvegicus | 1 | organism-based format | Scientific Literature |