# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4815911 | B | Activation of sGC (unknown origin) in presence of DETA-NO by Glosensor cGMP assay | Homo sapiens | 27 | ALA4813965 | protein complex format | Scientific Literature | |
2. | ALA4815912 | A | Intrinsic hepatic clearance in rat liver microsomes measured per mg of protein | Rattus norvegicus | 27 | ALA4813965 | microsome format | Scientific Literature | |
3. | ALA4815913 | A | Drug metabolism in rat assessed as formation of reactive and migrated acyl glucuronides metabolites | Rattus norvegicus | 9 | ALA4813965 | assay format | Scientific Literature | |
4. | ALA4815914 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 2 | ALA4813965 | microsome format | Scientific Literature | |
5. | ALA4815915 | A | Apparent permeability across apical to basolateral side of dog MDR1-MDCK2 cells | Canis lupus familiaris | 2 | ALA4813965 | tissue-based format | Scientific Literature | |
6. | ALA4815916 | P | Solubility of the compound at pH 7.0 | 2 | ALA4813965 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4815918 | A | Half life in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA4813965 | organism-based format | Scientific Literature | |
8. | ALA4815920 | A | Clearance in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA4813965 | organism-based format | Scientific Literature | |
9. | ALA4815921 | A | AUC in rat at 1 mg/kg, po | Rattus norvegicus | 2 | ALA4813965 | organism-based format | Scientific Literature | |
10. | ALA4815922 | A | Oral bioavailability in rat at 1 mg/kg | Rattus norvegicus | 2 | ALA4813965 | organism-based format | Scientific Literature | |
11. | ALA4815923 | B | Activation of human sGC assessed as increase in intracellular cGMP level in presence of DETA-NO | Homo sapiens | 1 | ALA4813965 | cell-based format | Scientific Literature | |
12. | ALA4815924 | B | Activation of human sGC assessed as increase in intracellular cGMP level in presence of DETA-NO and ODQ | Homo sapiens | 1 | ALA4813965 | cell-based format | Scientific Literature | |
13. | ALA4815925 | B | Activation of human sGC assessed as increase in intracellular cGMP level in presence of DETA-NO and Tween-20 | Homo sapiens | 1 | ALA4813965 | cell-based format | Scientific Literature | |
14. | ALA4815926 | F | Reduction in mean arterial blood pressure in po dosed normotensive Sprague-Dawley rat | Rattus norvegicus | 1 | ALA4813965 | organism-based format | Scientific Literature | |
15. | ALA4815927 | F | Reduction in mean arterial blood pressure in normotensive Sprague-Dawley rat at 30 mg/kg, po | Rattus norvegicus | 1 | ALA4813965 | organism-based format | Scientific Literature | |
16. | ALA4815929 | A | Drug metabolism in rat assessed as migration rate of acyl glucuronides metabolites incubated for 90 mins relative to control | Rattus norvegicus | 9 | ALA4813965 | assay format | Scientific Literature |