# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4824873 | A | Half life in mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
2. | ALA4824874 | F | In vivo inhibition of IDO1 in mouse xenografted with human SK-OV-3 cells assessed as reduction in tumor kynurenine AUEC at 20 mg/kg, po QD for 5 days measured up to 24 hrs after dosing relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
3. | ALA4824875 | A | Metabolic stability assessed as human CYP-mediated metabolism by measuring half life | Homo sapiens | 2 | protein format | Scientific Literature | ||
4. | ALA4824876 | B | Inhibition of IDO1 in IFNgamma-stimulated human HeLa cells preincubated for 2 hrs followed by recombinant human IFNgamma stimulation and measured after 18 hrs by fluorescence based microplate reader assay | Homo sapiens | 18 | tissue-based format | Scientific Literature | ||
5. | ALA4824877 | B | Inhibition of IDO1 in IFNgamma-stimulated mouse M109 cells preincubated for 2 hrs followed by recombinant murine IFNgamma stimulation and measured after 18 hrs by fluorescence based microplate reader assay | Mus musculus | 18 | tissue-based format | Scientific Literature | ||
6. | ALA4824878 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 0.5 uM after 10 mins incubation by LC-MS/MS analysis relative to control | Homo sapiens | 18 | microsome format | Scientific Literature | ||
7. | ALA4824879 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 0.5 uM after 10 mins incubation by LC-MS/MS analysis relative to control | Mus musculus | 18 | microsome format | Scientific Literature | ||
8. | ALA4824880 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 0.5 uM after 10 mins incubation by LC-MS/MS analysis relative to control | Rattus norvegicus | 6 | microsome format | Scientific Literature | ||
9. | ALA4824881 | B | Inhibition of IDO1 in IFNgamma/LPS-stimulated human whole blood preincubated for 4 hrs followed by IFNgamma/LPS stimulation and incubated for 18 hrs by Rapid-fire mass spectrometry analysis | Homo sapiens | 6 | tissue-based format | Scientific Literature | ||
10. | ALA4824882 | A | Metabolic stability assessed as mouse CYP-mediated metabolism by measuring half life | Mus musculus | 2 | assay format | Scientific Literature | ||
11. | ALA4824883 | A | Metabolic stability assessed as rat CYP-mediated metabolism by measuring half life | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
12. | ALA4824884 | A | Metabolic stability assessed as dog CYP-mediated metabolism by measuring half life | Canis lupus familiaris | 2 | assay format | Scientific Literature | ||
13. | ALA4824885 | A | Metabolic stability assessed as cynomolgus monkey CYP-mediated metabolism by measuring half life | Macaca fascicularis | 2 | assay format | Scientific Literature | ||
14. | ALA4824886 | A | Metabolic stability assessed as human UGT-mediated metabolism by measuring half life | Homo sapiens | 1 | protein format | Scientific Literature | ||
15. | ALA4824887 | A | Metabolic stability assessed as rat UGT-mediated metabolism by measuring half life | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
16. | ALA4824888 | A | Metabolic stability assessed as mouse UGT-mediated metabolism by measuring half life | Mus musculus | 1 | assay format | Scientific Literature | ||
17. | ALA4824889 | A | Metabolic stability assessed as dog UGT-mediated metabolism by measuring half life | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
18. | ALA4824890 | A | Metabolic stability assessed as cynomolgus monkey UGT-mediated metabolism by measuring half life | Macaca fascicularis | 1 | assay format | Scientific Literature | ||
19. | ALA4824891 | A | Apparent permeability of the compound at pH 7.4 by PAMPA | 1 | assay format | Scientific Literature | |||
20. | ALA4824892 | A | Apparent permeability across apical to basolateral side in human Caco-2 cells | Homo sapiens | 1 | cell-based format | Scientific Literature |