# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4819550 | B | Inhibition of recombinant human PDE4D (83 to 416 residues) expressed in Escherichia coli BL21 (DE3) assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assay | Homo sapiens | 52 | assay format | Scientific Literature | ||
2. | ALA4819552 | F | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha release measured after 24 hrs by ELISA | Mus musculus | 52 | cell-based format | Scientific Literature | ||
3. | ALA4819553 | A | Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell proliferation measured after 24 hrs by CCK-8 assay | Mus musculus | 52 | cell-based format | Scientific Literature | ||
4. | ALA4819554 | F | Anti-inflammatory activity against human PBMCs assessed as inhibition of LPS-induced TNF-alpha production preincubated for 1 hr followed by addition of LPS and measured after 20 hrs by ELISA method | Homo sapiens | 8 | tissue-based format | Scientific Literature | ||
5. | ALA4819556 | A | Permeability in human Caco2 cells assessed as compound recovery from apical to basal | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4819557 | A | Permeability in human Caco2 cells assessed as compound recovery from basal to apical | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
7. | ALA4819558 | A | Apparent permeability of compound in human Caco2 cells from apical to basal | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4819559 | A | Apparent permeability of compound in human Caco2 cells from basal to apical | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA4819560 | A | Permeability in human Caco-2 cells assessed as absorbed fraction | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA4819561 | A | Efflux ratio of apparent permeability across basolateral to apical membrane to apical to basolateral membrane in human Caco2 cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA4819562 | B | Inhibition of recombinant human PDE1A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
12. | ALA4819563 | B | Inhibition of recombinant human PDE2A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
13. | ALA4819564 | B | Inhibition of recombinant human PDE3A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
14. | ALA4819565 | B | Inhibition of recombinant human PDE4A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
15. | ALA4819566 | B | Inhibition of recombinant human PDE5A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
16. | ALA4819567 | B | Inhibition of recombinant human PDE6C assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
17. | ALA4819568 | B | Inhibition of recombinant human PDE7A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
18. | ALA4819569 | B | Inhibition of recombinant human PDE8A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
19. | ALA4819570 | B | Inhibition of recombinant human PDE9A assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
20. | ALA4819571 | B | Inhibition of recombinant human PDE10A assessed as hydrolysis of [3H]-cAMP at 10 uM measured after 30 mins by Scintillation proximity assay | Homo sapiens | 1 | single protein format | Scientific Literature |