| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4810626 | B | Displacement of Kinase tracer 236 from biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 1.5 hrs by TR-FRET assay | Homo sapiens | 65 | assay format | Scientific Literature | ||
| 2. | ALA4810627 | B | Binding affinity to biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as association constant measured up to 5 min by SPR method | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 3. | ALA4810628 | B | Binding affinity to biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation rate constant measured up to 5 min by SPR method | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 4. | ALA4810629 | B | Binding affinity to biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant measured up to 5 min by SPR method | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 5. | ALA4810630 | A | Metabolic stability in human liver microsomes | Homo sapiens | 17 | microsome format | Scientific Literature | ||
| 6. | ALA4810631 | A | Metabolic stability in rat liver microsomes | Rattus norvegicus | 17 | microsome format | Scientific Literature | ||
| 7. | ALA4810632 | P | Thermodynamic solubility of the compound at pH 6.8 | 17 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA4810633 | B | Inhibition of wild-type human partial length DYRK1A (H129 to S509 residues) expressed in mammalian expression system assessed as remaining activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 9. | ALA4810634 | B | Inhibition of wild-type human full length DYRK1B (M1 to S629 residues) expressed in bacterial expression system assessed as remaining activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 10. | ALA4810635 | B | Inhibition of wild-type human full length DYRK2 (M1 to S528 residues) expressed in mammalian expression system assessed as remaining activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 11. | ALA4810636 | B | Inhibition of wild-type human full length CLK1 (M1 to I484 residues) expressed in bacterial expression system assessed as remaining activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 12. | ALA4810637 | B | Inhibition of wild-type human partial length CLK2 (D144 to R498 residues) expressed in bacterial expression system assessed as remaining activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 13. | ALA4810638 | B | Inhibition of wild-type human full length CLK3 (M1 to R490 residues) expressed in bacterial expression system assessed as remaining activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 14. | ALA4810639 | B | Inhibition of wild-type human full length CDK2 (M1 to L298 residues) expressed in bacterial expression system assessed as remaining activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 15. | ALA4810640 | B | Inhibition of wild-type human full length GSK3B (M1 to T433 residues) expressed in mammalian expression system assessed as remaining activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 16. | ALA4810641 | B | Binding affinity to wild-type human partial length DYRK1A (H129 to S509 residues) expressed in mammalian expression system measured after 1 hr by competitive binding assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA4810642 | B | Binding affinity to wild-type human partial length HASPIN (I452 to K798 residues) expressed in mammalian expression system measured after 1 hr by competitive binding assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA4810643 | B | Binding affinity to wild-type human full length DYRK1B (M1 to S629 residues) expressed in bacterial expression system measured after 1 hr by competitive binding assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA4810644 | B | Binding affinity to wild-type human partial length CLK4 (R135 to K481 residues) expressed in bacterial expression system measured after 1 hr by competitive binding assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4810645 | B | Binding affinity to wild-type human full length CLK1 (M1 to I484 residues) expressed in bacterial expression system measured after 1 hr by competitive binding assay | Homo sapiens | 1 | assay format | Scientific Literature |
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