# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4824588 | B | Inhibition of human cytomegalovirus pUL89 endonuclease activity using 60 bp dsDNA substrate at 20 uM incubated for 30 mins by ELISA-based biochemical assay relative to control | Human betaherpesvirus 5 | 42 | single protein format | Scientific Literature | ||
2. | ALA4824589 | F | Antiviral activity against human cytomegalovirus expressing ADCREGFP infected in human HEL 299 cells assessed as reduction in viral replication by measuring GFP fluorescence at 10 uM incubated for 168 hrs by cell based assay relative to control | Human betaherpesvirus 5 | 43 | cell-based format | Scientific Literature | ||
3. | ALA4824590 | A | Cytotoxicity against human HEL 299 cells assessed as cell viability at 10 uM incubated for 168 hrs by MTS-based tetrazolium reduction assay relative to control | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
4. | ALA4824591 | B | Inhibition of human cytomegalovirus pUL89 endonuclease activity using 60 bp dsDNA substrate incubated for 30 mins by ELISA-based biochemical assay | Human betaherpesvirus 5 | 24 | single protein format | Scientific Literature | ||
5. | ALA4824592 | B | Binding affinity to human cytomegalovirus pUL89 assessed as change in melting temperature at 20 uM by thermal shift assay | Human betaherpesvirus 5 | 25 | single protein format | Scientific Literature | ||
6. | ALA4824593 | A | Apparent permeability of the compound incubated for 5 hrs by LC-MS/MS analysis based PAMPA method | 13 | assay format | Scientific Literature | |||
7. | ALA4824594 | F | Antiviral activity against human cytomegalovirus expressing ADCREGFP infected in human HEL 299 cells assessed as reduction in viral replication by measuring GFP fluorescence incubated for 168 hrs by cell based assay | Human betaherpesvirus 5 | 14 | cell-based format | Scientific Literature | ||
8. | ALA4824595 | A | Cytotoxicity against human HEL 299 cells assessed as cell death incubated for 168 hrs by MTS-based tetrazolium reduction assay | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
9. | ALA4824596 | T | Selectivity index, ratio of CC50 for human HEL 299 cells to EC50 for antiviral activity against human cytomegalovirus expressing ADCREGFP infected in human Hel-299 cells assessed as reduction in viral replication by measuring GFP fluorescence incubated for 168 hrs by cell based assay | 14 | cell-based format | Scientific Literature | |||
10. | ALA5163695 | F | Antiviral activity against human cytomegalovirus expressing ADCREGFP infected in HFF cells assessed as inhibition in viral replication by measuring GFP fluorescence incubated for 168 hrs by cell based assay | Cytomegalovirus | 10 | organism-based format | Scientific Literature | ||
11. | ALA5163696 | T | Cytotoxicity against HFF cells assessed as cell viability incubated for 168 hrs by MTS-based Cell Titer assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
12. | ALA5163697 | T | Selectivity index, ratio of CC50 for cytotoxicity against HFF cells to EC50 for antiviral activity against human cytomegalovirus expressing ADCREGFP infected in HFF cells | 10 | cell-based format | Scientific Literature | |||
13. | ALA5163711 | B | Inhibition of human cytomegalovirus pUL89-C | Cytomegalovirus | 1 | single protein format | Scientific Literature |