| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4824242 | B | Inhibition of recombinant His-tagged Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli BL2(DE3) using TS2 as substrate by spectrophotometric assay | Leishmania infantum | 29 | assay format | Scientific Literature | ||
| 2. | ALA4824244 | B | Inhibition of recombinant His-FLAG-tagged Leishmania infantum TryR dimerization expressed in Escherichia coli BL2(DE3) assessed as reduction in TryR dimer using TS2 as substrate after 16 hrs by ELISA | Leishmania infantum | 27 | assay format | Scientific Literature | ||
| 3. | ALA4824245 | B | Inhibition of recombinant His-FLAG-tagged Leishmania infantum TryR dimerization expressed in Escherichia coli BL2(DE3) assessed as reduction in TryR dimer at 20 uM using TS2 as substrate after 16 hrs by ELISA relative to control | Leishmania infantum | 4 | assay format | Scientific Literature | ||
| 4. | ALA4824246 | B | Inhibition of recombinant human GR oxidoreductase activity by DTNB-reagent based spectrophotometric method | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 5. | ALA4824258 | B | Inhibition of Trypanosoma brucei TryR oxidoreductase activity using TS2 as substrate by spectrophotometric assay | Trypanosoma brucei | 7 | single protein format | Scientific Literature | ||
| 6. | ALA4824259 | B | Inhibition of Trypanosoma congolense TryR oxidoreductase activity using TS2 as substrate by spectrophotometric assay | Trypanosoma congolense | 7 | assay format | Scientific Literature | ||
| 7. | ALA4824261 | F | Antileishmanial activity against promastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human HepG2 cells incubated for 24 hrs by propidium iodide staining based flow cytometry | Leishmania infantum | 23 | organism-based format | Scientific Literature | ||
| 8. | ALA4824262 | F | Antileishmanial activity against axenic amastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human HepG2 cells incubated for 24 hrs by propidium iodide staining based flow cytometry | Leishmania infantum | 23 | organism-based format | Scientific Literature | ||
| 9. | ALA4824263 | A | Cytotoxicity against human HepG2 cells incubated for 24 hrs by crystal violet staining based assay | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 10. | ALA4824264 | T | Selectivity index, ratio of EC50 for human HepG2 cells to EC50 for promastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human HepG2 cells | 23 | cell-based format | Scientific Literature | |||
| 11. | ALA4824265 | T | Selectivity index, ratio of EC50 for human HepG2 cells to EC50 for axenic amastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human HepG2 cells | 23 | cell-based format | Scientific Literature | |||
| 12. | ALA4824266 | F | Leishmanicidal activity against axenic amastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human THP-1 macrophage cells assessed as reduction in intracellular amastigotes incubated for 24 hrs by propidium iodide staining based flow cytometry | Leishmania infantum | 13 | organism-based format | Scientific Literature | ||
| 13. | ALA4824267 | A | Cytotoxicity against human THP-1 cells by LDH assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 14. | ALA4824268 | A | Cytotoxicity against human THP-1 cells at 75 uM by LDH assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 15. | ALA5250787 | P | Thermodynamic aqueous solubility of compound at 25 degreeC measured after 24 hrs by HPLC analysis | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 16. | ALA5250800 | F | Antileishmanial activity against GFP-expressing Leishmania infantum intracellular amastigotes infected in human THP-1 derived macrophage cells assessed as reduction in parasite viability measured for 72 hrs by resazurin/alamar blue fluorometric assay | Leishmania infantum | 14 | organism-based format | Scientific Literature | ||
| 17. | ALA5250801 | T | Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation measured after 72 hrs by crystal violet staining based analysis | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 18. | ALA5250802 | T | Selectivity index, ratio of CC50 for human HepG2 cells to EC50 for GFP-expressing Leishmania infantum intracellular amastigotes infected in human THP-1 derived macrophage cells | 14 | cell-based format | Scientific Literature |
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