# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4830153 | Binding | Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30 mins in presence of ATP by TR-FRET assay | Homo sapiens | 18 | ALA4828736 | assay format | Scientific Literature | |
2. | ALA4830154 | Functional | Antiproliferative activity against human A-375 cells assessed as reduction in cell viability after 96 hrs by alamar blue assay | Homo sapiens | 23 | ALA4828736 | cell-based format | Scientific Literature | |
3. | ALA4830157 | ADME | Metabolic stability in human liver microsomes assessed as half life at 1 uM measured upto 40 mins in presence of NADPH and UDPGA | Homo sapiens | 23 | ALA4828736 | microsome format | Scientific Literature | |
4. | ALA4830158 | ADME | Metabolic stability assessed as human CYP3A4-mediated metabolism by measuring half life at 1 uM measured after 40 mins in presence of NADPH | Homo sapiens | 18 | ALA4828736 | single protein format | Scientific Literature | |
5. | ALA4830159 | Physicochemical | Lipophilicity, log D of the compound at pH 7.4 by chromatographic method | 16 | ALA4828736 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4830160 | ADME | Clearance in BALB/c mouse at 0.5 mg/kg, iv measured upto 24 hrs | Mus musculus | 16 | ALA4828736 | organism-based format | Scientific Literature | |
7. | ALA4830161 | ADME | Volume of distribution at steady state in BALB/c mouse at 0.5 mg/kg, iv measured upto 24 hrs | Mus musculus | 16 | ALA4828736 | organism-based format | Scientific Literature | |
8. | ALA4830162 | ADME | AUC in BALB/c mouse at 5 mg/kg, po measured upto 24 hrs | Mus musculus | 16 | ALA4828736 | organism-based format | Scientific Literature | |
9. | ALA4830163 | ADME | Half life in BALB/c mouse at 5 mg/kg, po measured upto 24 hrs | Mus musculus | 15 | ALA4828736 | organism-based format | Scientific Literature | |
10. | ALA4830164 | ADME | Oral bioavailability in BALB/c mouse at 5 mg/kg measured upto 24 hrs | Mus musculus | 15 | ALA4828736 | organism-based format | Scientific Literature |