| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4831149 | F | Growth inhibition of human MDA-MB-468 cells assessed as cell viability measured after 4 days by WST8 assay | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
| 2. | ALA4831150 | F | Growth inhibition of human BT-549 cells assessed as cell viability measured after 4 days by WST8 assay | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
| 3. | ALA4831151 | F | Growth inhibition of human MDA-MB-231 cells assessed as cell viability measured after 4 days by WST8 assay | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
| 4. | ALA4831158 | B | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 pretreated with MLN4924 at 500 nM incubated for 8 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4831172 | B | Protac activity at CRBN/CDK1 in human MDA-MB-231 cells assessed as induction of degradation of CDK1 at 100 to 500 nM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4831173 | B | Protac activity at CRBN/CDK2 in human MDA-MB-231 cells assessed as induction of degradation of CDK2 at 100 to 500 nM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4831174 | B | Protac activity at CRBN/CDK4 in human MDA-MB-231 cells assessed as induction of degradation of CDK4 at 100 to 500 nM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4831175 | B | Protac activity at CRBN/CDK5 in human MDA-MB-231 cells assessed as induction of degradation of CDK5 at 100 to 500 nM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4831176 | B | Protac activity at CRBN/CDK6 in human MDA-MB-231 cells assessed as induction of degradation of CDK6 at 100 to 500 nM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4831177 | B | Protac activity at CRBN/CDK7 in human MDA-MB-231 cells assessed as induction of degradation of CDK7 at 100 to 500 nM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4831178 | B | Protac activity at CRBN/GSPT1 in human MDA-MB-231 cells assessed as induction of degradation of GSPT1 incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4831179 | F | Induction of CDK9 degradation in tumor of human MDA-MB-231 cells xenografted in BALB/c mouse model at 0.15 mM intratumoral injection measured after 16 hrs by Western blot analysis relative to control | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 13. | ALA4831180 | F | Induction of CDK7 degradation in tumor of human MDA-MB-231 cells xenografted in BALB/c mouse model at 0.15 mM intratumoral injection measured after 16 hrs by Western blot analysis relative to control | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 14. | ALA4831181 | F | Antitumor activity against human MDA-MB-231 cells xenografted in BALB/c mouse model assessed as decrease in tumor volume at 2.5 mg/kg, intratumoral injection daily for 7 days relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4831182 | F | Antitumor activity against human MDA-MB-231 cells xenografted in BALB/c mouse model assessed as decrease in tumor volume at 5 mg/kg, intratumoral injection daily for 7 days relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4831183 | T | Toxicity in BALB/c mouse xenografted with human MDA-MB-231 cells assessed as body weight loss at 2.5 mg/kg, intratumoral injection daily for 7 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4831184 | T | Toxicity in BALB/c mouse xenografted with human MDA-MB-231 cells assessed as body weight loss at 5 mg/kg, intratumoral injection daily for 7 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4831185 | F | Antitumor activity against human MDA-MB-231 cells xenografted in BALB/c mouse model assessed as induction of CDK9 degradation in tumor tissue at 2.5 mg/kg, intratumoral injection daily for 7 days by Western blot analysis relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4831186 | F | Antitumor activity against human MDA-MB-231 cells xenografted in BALB/c mouse model assessed as induction of CDK9 degradation in tumor tissue at 5 mg/kg, intratumoral injection daily for 7 days by Western blot analysis relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4831187 | F | Effect on CDK7 protein level in tumor of BALB/c mouse xenografted with human MDA-MB-231 cells at 2.5 to 5 mg/kg, intratumoral injection daily for 7 days by Western blot analysis relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature |
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