# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4821399 | Binding | Inhibition of porcine liver carboxylesterase using 4-NPA as substrate preincubated for 10 mins followed by substrate addition by spectrophotometric analysis | Sus scrofa | 25 | ALA4819068 | tissue-based format | Scientific Literature | |
2. | ALA4821401 | Binding | Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | Homo sapiens | 16 | ALA4819068 | single protein format | Scientific Literature | |
3. | ALA4821403 | Binding | Inhibition of equine serum BuChE using butyrylcholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | Equus caballus | 17 | ALA4819068 | single protein format | Scientific Literature | |
4. | ALA4821405 | Functional | Antioxidant activity assessed as trolox equivalent of ABTS radical cation scavenging activity incubated for 24 hrs by UV-Vis spectrophotometric analysis | 26 | ALA4819068 | assay format | Scientific Literature | ||
5. | ALA4821406 | Functional | Antioxidant activity assessed as decrease in ABTS radical cation scavenging activity incubated for 24 hrs by UV-Vis spectrophotometric analysis | 26 | ALA4819068 | assay format | Scientific Literature | ||
6. | ALA4821414 | Binding | Inhibition of human recombinant CES1 expressed in baculovirus infected BTI insect cells using 4-NPA as substrate by spectrophotometric analysis | Homo sapiens | 13 | ALA4819068 | cell-based format | Scientific Literature | |
7. | ALA4821415 | Binding | Inhibition of human recombinant CES2 expressed in mouse NSO cells using 4-NPA as substrate by spectrophotometric analysis | Homo sapiens | 13 | ALA4819068 | cell-based format | Scientific Literature | |
8. | ALA4821416 | Binding | Selectivity index, ratio of IC50 for inhibition of human CES2 to IC50 for inhibition of human CES1 | Homo sapiens | 13 | ALA4819068 | assay format | Scientific Literature | |
9. | ALA4821417 | ADME | Cytotoxicity against human FetMSC cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 8 | ALA4819068 | cell-based format | Scientific Literature | |
10. | ALA4821418 | Toxicity | Acute toxicity in ip dosed CD-1 mouse observed for 14 days | Mus musculus | 8 | ALA4819068 | organism-based format | Scientific Literature | |
11. | ALA4821420 | Toxicity | Acute toxicity in CD-1 mouse assessed as effect on mouse death at 900 mg/kg, ip measured after 14 days | Mus musculus | 1 | ALA4819068 | organism-based format | Scientific Literature |