| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4816050 | F | Antiproliferative activity against human BT-474 cells overexpressing HER2 assessed as cell growth inhibition incubated for 72 hrs by cell titer glo assay | Homo sapiens | 9 | ALA4813972 | cell-based format | Scientific Literature | |
| 2. | ALA4816051 | F | Antiproliferative activity against human MCF7 cells with silenced HER2 assessed as cell growth inhibition incubated for 72 hrs by cell titer glo assay | Homo sapiens | 9 | ALA4813972 | cell-based format | Scientific Literature | |
| 3. | ALA4816052 | F | Antiproliferative activity against human Calu-3 cells overexpressing HER2 assessed as cell growth inhibition incubated for 72 hrs by cell titer glo assay | Homo sapiens | 9 | ALA4813972 | cell-based format | Scientific Literature | |
| 4. | ALA4816053 | F | Antiproliferative activity against human A549 cells overexpressing HER2 assessed as cell growth inhibition incubated for 72 hrs by cell titer glo assay | Homo sapiens | 9 | ALA4813972 | cell-based format | Scientific Literature | |
| 5. | ALA4816054 | A | Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by cell titer glo assay | Homo sapiens | 4 | ALA4813972 | cell-based format | Scientific Literature | |
| 6. | ALA4816055 | B | Binding affinity to HER2 ECD (unknown origin) by SPR analysis | Homo sapiens | 1 | ALA4813972 | single protein format | Scientific Literature | |
| 7. | ALA4816056 | B | Binding affinity to HER2 domain IV (unknown origin) by SPR analysis | Homo sapiens | 1 | ALA4813972 | single protein format | Scientific Literature | |
| 8. | ALA4816057 | B | Binding affinity to HER2 (unknown origin) assessed as reduction in heterodimerization of HER2/EGFR by competitive based SPR analysis | Homo sapiens | 1 | ALA4813972 | single protein format | Scientific Literature | |
| 9. | ALA4816058 | B | Inhibition of HER2/EGFR dimerization in human A549 cells incubated for 48 hrs by proximity ligation assay | Homo sapiens | 1 | ALA4813972 | cell-based format | Scientific Literature | |
| 10. | ALA4816059 | B | Inhibition of HER2/HER3 dimerization in human A549 cells incubated for 48 hrs by proximity ligation assay | Homo sapiens | 1 | ALA4813972 | cell-based format | Scientific Literature | |
| 11. | ALA4816060 | B | Inhibition of HER2/EGFR dimerization in human Calu-3 cells incubated for 48 hrs by proximity ligation assay | Homo sapiens | 1 | ALA4813972 | cell-based format | Scientific Literature | |
| 12. | ALA4816061 | B | Inhibition of HER2 ECD in human A549 cells assessed as reduction in HER2 intracellular kinase domain phosphorylation at 1 uM incubated for 40 hrs by Western blot analysis | Homo sapiens | 1 | ALA4813972 | cell-based format | Scientific Literature | |
| 13. | ALA4816063 | F | Effect on HER2 expression in human A549 cells at 1 uM incubated for 40 hrs by Western blot analysis | Homo sapiens | 1 | ALA4813972 | cell-based format | Scientific Literature | |
| 14. | ALA4816064 | B | Inhibition of HER2 ECD in human A549 cells assessed as reduction in Akt phosphorylation at 1 uM incubated for 40 hrs by Western blot analysis | Homo sapiens | 1 | ALA4813972 | cell-based format | Scientific Literature | |
| 15. | ALA4816065 | P | Thermal stability of compound at 15 uM incubated at 25 to 75 degC by Circular dichroism spectrometry | 1 | ALA4813972 | small-molecule physicochemical format | Scientific Literature | ||
| 16. | ALA4816066 | P | Thermal stability of compound at 15 uM incubated at 25 to 75 degC by MALDI-TOF analysis | 1 | ALA4813972 | small-molecule physicochemical format | Scientific Literature | ||
| 17. | ALA4816067 | P | Thermal stability of compound at 15 uM incubated at 25 to 75 degC in presence of DTT by circular dichroism spectrometry | 1 | ALA4813972 | small-molecule physicochemical format | Scientific Literature | ||
| 18. | ALA4816068 | F | Antitumor activity in human Calu-3 cells xenografted in Foxn1nu/Foxn1+ mouse assessed as reduction in tumor growth at 8 mg/kg, IT(Intratumoral) administered thrice a week for 21 days and measured on day 21 relative to control | Homo sapiens | 1 | ALA4813972 | organism-based format | Scientific Literature | |
| 19. | ALA4816071 | T | Toxicity in Foxn1nu/Foxn1+ mouse xenografted with human Calu-3 cells assessed as effect on body weight at 8 mg/kg, IT(Intratumoral) administered thrice a week for 28 days and measured on day 28 | Mus musculus | 1 | ALA4813972 | organism-based format | Scientific Literature | |
| 20. | ALA4816072 | T | Toxicity in Foxn1nu/Foxn1+ mouse xenografted with human Calu-3 cells assessed as clinical observation at 8 mg/kg, IT(Intratumoral) administered thrice a week for 28 days and measured on day 28 | Mus musculus | 1 | ALA4813972 | organism-based format | Scientific Literature |
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