| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4833228 | B | Inhibition of NLRC4 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion at 2 uM preincubated for 30 mins followed by Salmonella addition and measured after 4 hrs by ELISA | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 2. | ALA4833230 | A | Cytotoxicity against human L-02 cells incubated for 24 hrs by MTT assay | Homo sapiens | 53 | cell-based format | Scientific Literature | ||
| 3. | ALA4833231 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse J774A.1 cells assessed as inhibition of cell pyrolysis at 10 uM incubated for 1 hr followed by ATP addition and measured after 30 mins by Hoechst 33342/propidium iodide staining based high content screening method relative to control | Mus musculus | 50 | tissue-based format | Scientific Literature | ||
| 4. | ALA4833232 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by nigericin addition and measured after 30 mins by ELISA | Mus musculus | 14 | tissue-based format | Scientific Literature | ||
| 5. | ALA4833233 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in cleaved IL-1beta secretion preincubated for 30 mins followed by nigericin addition and measured after 30 mins by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 6. | ALA4833234 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in caspase1 p20 secretion preincubated for 30 mins followed by nigericin addition and measured after 30 mins by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 7. | ALA4833235 | F | Effect on pro-IL1beta expression in LPS-stimulated mouse bone marrow-derived macrophages at 0.5 to 2 uM preincubated for 30 mins followed by nigericin addition and measured after 30 mins by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 8. | ALA4833236 | F | Effect on pro-caspase1(p45) expression in LPS-stimulated mouse bone marrow-derived macrophages at 0.5 to 2 uM preincubated for 30 mins followed by nigericin addition and measured after 30 mins by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 9. | ALA4833237 | F | Effect on NEK7 expression in LPS-stimulated mouse bone marrow-derived macrophages at 0.5 to 2 uM preincubated for 30 mins followed by nigericin addition and measured after 30 mins by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 10. | ALA4833238 | F | Effect on NLRP3 expression in LPS-stimulated mouse bone marrow-derived macrophages at 0.5 to 2 uM preincubated for 30 mins followed by nigericin addition and measured after 30 mins by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 11. | ALA4833239 | F | Effect on ASC expression in LPS-stimulated mouse bone marrow-derived macrophages at 0.5 to 2 uM preincubated for 30 mins followed by nigericin addition and measured after 30 mins by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 12. | ALA4833240 | F | Effect on pro-caspase1 expression in LPS-stimulated mouse bone marrow-derived macrophages at 0.5 to 2 uM preincubated for 30 mins followed by nigericin addition and measured after 30 mins by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 13. | ALA4833241 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in cell pyrolysis at 5 to 25 uM preincubated for 30 mins followed by nigericin addition and measured after 30 mins by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 14. | ALA4833242 | B | Inhibition of NFkappaB activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in TNFalpha secretion at 0.5 to 2 uM preincubated for 30 mins followed by nigericin addition and measured after 30 mins by ELISA | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 15. | ALA4833243 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in cleaved IL-1beta secretion in supernatant at 2 uM preincubated for 30 mins followed by nigericin addition and measured after 0.5 hrs by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 16. | ALA4833244 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in activated caspase1 p20 in supernatant at 2 uM preincubated for 30 mins followed by nigericin addition and measured after 0.5 hrs by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 17. | ALA4833245 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in pro IL-1beta secretion in cell lysate at 2 uM preincubated for 30 mins followed by nigericin addition and measured after 0.5 hrs by Western blot analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 18. | ALA4833246 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in pro caspase1 secretion in cell lysate at 2 uM preincubated for 30 mins followed by nigericin addition and measured after 0.5 hrs by Western blot analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 19. | ALA4833247 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in ILbeta secretion at 2 uM preincubated for 30 mins followed by nigericin addition and measured after 0.5 hrs by ELISA | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 20. | ALA4833248 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse bone marrow-derived macrophages assessed as reduction in cleaved IL-1beta secretion in supernatant at 2 uM preincubated for 30 mins followed by ATP addition and measured after 0.5 hrs by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature |
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