# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4835944 | B | Displacement of [125I]CGRP from human CGRP receptor in human SK-N-MC cells measured after 2 hrs by scintillation counting analysis | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
2. | ALA4835945 | A | Microsomal stability in human liver microsomes assessed as parent compound remaining at 0.5 M measured after 10 mins | Homo sapiens | 15 | microsome format | Scientific Literature | ||
3. | ALA4835946 | A | Microsomal stability in rat microsomes assessed as parent compound remaining at 0.5 M measured after 10 mins | Rattus norvegicus | 15 | microsome format | Scientific Literature | ||
4. | ALA4835947 | A | Microsomal stability in monkey microsomes assessed as parent compound remaining at 0.5 M measured after 10 mins | Macaca mulatta | 15 | microsome format | Scientific Literature | ||
5. | ALA4835948 | A | Cmax in rat at 10 mg/kg, po | Rattus norvegicus | 15 | organism-based format | Scientific Literature | ||
6. | ALA4835950 | A | Time dependent inhibition of CYP3A4 (unknown origin) measured after 30 mins | Homo sapiens | 4 | single protein format | Scientific Literature | ||
7. | ALA4835951 | F | Antimigraine activity in human CGRPalpha-induced migraine marmoset model assessed as reduction in facial blood flow at 7 mg/kg, sc administered 30 mins after CGRPalpha stimulation measured after 15 mins by laser doppler method relative to control | Callithrix jacchus | 3 | organism-based format | Scientific Literature | ||
8. | ALA4835952 | F | Antimigraine activity in human CGRPalpha-induced migraine marmoset model assessed as reduction in facial blood flow at 7 mg/kg, sc administered 30 mins after CGRPalpha stimulation measured after 60 mins by laser doppler method relative to control | Callithrix jacchus | 3 | organism-based format | Scientific Literature | ||
9. | ALA4835953 | F | Antimigraine activity in human CGRPalpha-induced migraine marmoset model assessed as reduction in facial blood flow at 7 mg/kg, sc administered 30 mins after CGRPalpha stimulation measured after 105 mins by laser doppler method relative to control | Callithrix jacchus | 3 | organism-based format | Scientific Literature | ||
10. | ALA4835956 | A | Total plasma concentration in human CGRPalpha-induced migraine marmoset model at 7 mg/kg, sc measured after 15 to 105 mins | Callithrix jacchus | 3 | organism-based format | Scientific Literature | ||
11. | ALA4835959 | A | Fraction unbound in plasma of human CGRPalpha-induced migraine marmoset model at 7 mg/kg, sc measured after 15 to 105 mins | Callithrix jacchus | 3 | organism-based format | Scientific Literature | ||
12. | ALA4835961 | A | Permeability of compound at pH 5.5 by PAMPA assay | 4 | assay format | Scientific Literature | |||
13. | ALA4835962 | A | Permeability of compound at pH 7.4 by PAMPA assay | 4 | assay format | Scientific Literature | |||
14. | ALA4835963 | A | Permeability form apical to basolateral side in human Caco2 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
15. | ALA4835964 | A | Permeability form basolateral to apical side in human Caco2 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
16. | ALA4835965 | P | Solubility in phosphate buffer at pH 7 using amorphous form of sample | 4 | small-molecule physicochemical format | Scientific Literature |