# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4810314 | Binding | Inhibition of SARS-CoV-2 3CLpro preincubated for 30 mins followed by addition of (Dabcyl)KTSAVLQSGFRKM(Glu) peptide substrate and measured after 1.5 hrs by FRET assay | Severe acute respiratory syndrome coronavirus 2 | 15 | ALA4808212 | single protein format | Scientific Literature | |
2. | ALA4827057 | Binding | Inhibition of SARS CoV-2 main protease expressed in Escherichia coli BL21 (DE3) using Abz-SVTLQSG-Y(NO2)-R as substrate by FRET based assay | Severe acute respiratory syndrome coronavirus 2 | 22 | ALA4825695 | assay format | Scientific Literature | |
3. | ALA4827058 | Functional | Antiviral activity against SARS-CoV-2 infected in African Green monkey Vero E6 cells assessed as reduction in viral plaques incubated for 48 hrs by quantitative RT-PCR assay | Severe acute respiratory syndrome coronavirus 2 | 22 | ALA4825695 | organism-based format | Scientific Literature | |
4. | ALA4827059 | Functional | Antiviral activity against SARS-CoV-2 infected in African Green monkey Vero E6 cells assessed as reduction in viral plaques in presence of efflux inhibitor CP-100356 incubated for 48 hrs by quantitative RT-PCR assay | Severe acute respiratory syndrome coronavirus 2 | 22 | ALA4825695 | organism-based format | Scientific Literature | |
5. | ALA4827060 | ADME | Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability after 24 hrs by CellTiter-Glo luminescent cell viability assay | Chlorocebus sabaeus | 22 | ALA4825695 | cell-based format | Scientific Literature | |
6. | ALA4827062 | Physicochemical | Solubility in D2O assessed as diffusion coefficient at 440 mM by diffusion-ordered spectroscopy (DOSY) analysis | 1 | ALA4825695 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4827063 | Physicochemical | Solubility in D2O assessed as diffusion coefficient at 5 mM by diffusion-ordered spectroscopy (DOSY) analysis | 1 | ALA4825695 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4827064 | Physicochemical | Solubility in D2O assessed as disperse at 440 mM by NMR spectra analysis | 1 | ALA4825695 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4827065 | Physicochemical | Solubility in D2O assessed as disperse at 5 mM by NMR spectra analysis | 1 | ALA4825695 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4827066 | Physicochemical | Solubility in D2O assessed as critical micelle concentration by NMR spectra analysis | 2 | ALA4825695 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA5225076 | Binding | Inhibition of recombinant SARS-CoV-2 Main protease expressed in Escherichia coli BL21 (DE3) using Abz-SVTLQSG-Y(NO2)-R as substrate incubated for 10 mins by FRET assay | Severe acute respiratory syndrome coronavirus 2 | 2 | ALA5223130 | assay format | Scientific Literature | |
12. | ALA5225079 | Functional | Antiviral activity against SARS-CoV-2/CANADA/VIDO 01/2020 infected in African green monkey Vero E6 cells assessed as inhibition of plaque formation measured after 48 hrs by crystal violet staining based analysis | Severe acute respiratory syndrome coronavirus 2 | 2 | ALA5223130 | organism-based format | Scientific Literature | |
13. | ALA5247325 | Binding | Inhibition of SARS CoV Main protease by FRET assay | Severe acute respiratory syndrome-related coronavirus | 12 | ALA5244279 | assay format | Scientific Literature | |
14. | ALA5247326 | Functional | Antiviral activity against SARS CoV-2 infected in African green monkey Vero E6 cells by plaque assay | Severe acute respiratory syndrome coronavirus 2 | 11 | ALA5244279 | organism-based format | Scientific Literature | |
15. | ALA5247327 | Toxicity | Cytotoxicity against human Huh-7 cells assessed as reduction of cell viability | Homo sapiens | 14 | ALA5244279 | cell-based format | Scientific Literature | |
16. | ALA5247328 | Toxicity | Cytotoxicity against cat CRFK cells assessed as reduction of cell viability | Felis catus | 14 | ALA5244279 | cell-based format | Scientific Literature | |
17. | ALA5247329 | Toxicity | Cytotoxicity against mouse L929 cells assessed as reduction of cell viability | Mus musculus | 14 | ALA5244279 | cell-based format | Scientific Literature | |
18. | ALA5254928 | Binding | Inhibition of SARS-CoV-2 3CL protease measured after 10 mins by FRET assay | Severe acute respiratory syndrome coronavirus 2 | 2 | ALA5252565 | single protein format | Scientific Literature |