| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4810087 | F | Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as reduction in HBsAg level measured after 4 days by AlphaLisa assay | Hepatitis B virus | 9 | organism-based format | Scientific Literature | ||
| 2. | ALA4810088 | P | 1-Octanol/saturated PBS buffer distribution coefficient, logD of the compound incubated for 1 hr by LC-MS/MS analysis | 9 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA4810089 | A | Apparent permeability across apical to basolateral side in MDCK-MDR1 cells at 1 uM measured after 120 mins by LC-MS/MS analysis | Canis lupus familiaris | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4810090 | A | Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability measured after 4 days by CellTiter-Glo reagent based assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 5. | ALA4810091 | A | Apparent permeability across basolateral to apical side in MDCK-MDR1 cells at 1 uM measured after 120 mins by LC-MS/MS analysis | Canis lupus familiaris | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4810092 | A | Ratio of drug uptake in HEK293 cells transfected with OATP1B3 (unknown origin) in absence of transporter inhibitor, estradiol-17beta-glucuronide to drug uptake in HEK293 cells in absence of transporter inhibitor, estradiol-17beta-glucuronide by LC-MS/MS analysis | 2 | cell-based format | Scientific Literature | |||
| 7. | ALA4810093 | A | Substrate activity at OATP1B3 (unknown origin) expressed in HEK293 cells assessed as ratio of drug uptake in absence of transporter inhibitor, estradiol-17beta-glucuronide to drug uptake in presence of transporter inhibitor, estradiol-17beta-glucuronide by LC-MS/MS analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4810094 | F | Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as reduction in HBV pregenomic mRNA level at 1 uM measured after 5 days by Northern blot analysis | Hepatitis B virus | 2 | organism-based format | Scientific Literature | ||
| 9. | ALA4810095 | B | Inhibition of Myc-DDK-tagged human PAPD5 expressed in HEK293 cells assessed as inhibition of poly-adenylation reaction using P32-labeled RNA oligonucleotides (5'-GCCUUUCAUCUCUAACUGCGAAAAAAAAAA-3') as substrate measured for 20 mins by phosphor imaging analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4810096 | B | Inhibition of human PAPD7 expressed in HEK293 cells assessed as inhibition of poly-adenylation reaction using P32-labeled RNA oligonucleotides (5'-GCCUUUCAUCUCUAACUGCGAAAAAAAAAA-3') as substrate measured for 3 hrs by phosphor imaging analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4810097 | A | Efflux ratio of apparent permeability in MDCK-MDR1 cells at 1 uM after 120 mins by LC-MS/MS analysis | Canis lupus familiaris | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4810098 | A | Metabolic stability in human liver microsomes assessed as clearance preincubated with compound for 10 mins followed by NADPH regenerating system addition and measured per mg protein for 60 mins by LC/MS-MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 13. | ALA4810099 | A | Metabolic stability in mouse liver microsomes assessed as clearance preincubated with compound for 10 mins followed by NADPH regenerating system addition and measured per mg protein for 60 mins by LC/MS-MS analysis | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 14. | ALA4810100 | A | Metabolic stability in mouse liver microsomes assessed as half life preincubated with compound for 10 mins followed by NADPH regenerating system addition and measured for 60 mins by LC/MS-MS analysis | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 15. | ALA4810101 | A | Apparent permeability of the compound across apical to basolateral side in human Caco-2 cells at 10 uM incubated for 1 hr | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4810102 | A | Apparent permeability of the compound across basolateral to apical side in human Caco-2 cells at 10 uM incubated for 1 hr | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4810103 | A | Efflux ratio of apparent permeability in human Caco-2 cells at 10 uM incubated for 1 hr | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4810104 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 19. | ALA4810105 | A | Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 20. | ALA4810106 | A | Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature |
The page will load shortly, Thanks for your patience!