| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4832319 | B | Inhibition of human KDM4D expressed in Escherichia coli BL21 (DE3) at 1 uM using biotinylated H3-derived peptide and 2-OG as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by AlphaLISA assay | Homo sapiens | 71 | assay format | Scientific Literature | ||
| 2. | ALA4832320 | B | Inhibition of human KDM4D expressed in Escherichia coli BL21 (DE3) using biotinylated H3-derived peptide and 2-OG as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by AlphaLISA assay | Homo sapiens | 54 | assay format | Scientific Literature | ||
| 3. | ALA4832321 | B | Inhibition of human KDM4D expressed in Escherichia coli BL21 (DE3) assessed as equilibrium dissociation constant measured by isothermal titration calorimetry assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA4832322 | B | Binding affinity to human KDM4D expressed in Escherichia coli BL21(DE3) assessed as negative thermal shift in melting temperature measured for 60 mins by differential scanning fluorimetry assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 5. | ALA4832323 | B | Mixed inhibition of human KDM4D expressed in Escherichia coli BL21(DE3) using H3(1-21)K9me3 peptide and varying concentrations of 2-OG as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by Michaelis-Menten plot based analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 6. | ALA4832324 | B | Inhibition of KDM3B (unknown origin) by AlphaLISA assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4832325 | B | Inhibition of KDM4A (unknown origin) by AlphaLISA assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA4832326 | B | Inhibition of KDM5A (unknown origin) by AlphaLISA assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA4832327 | B | Inhibition of KDM6A (unknown origin) by AlphaLISA assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA4832328 | B | Selectivity index, ratio of IC50 for KDM3B (unknown origin) to IC50 for human KDM4D expressed in Escherichia coli (BL21)DE3 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA4832329 | B | Selectivity index, ratio of IC50 for KDM4A (unknown origin) to IC50 for human KDM4D expressed in Escherichia coli (BL21)DE3 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA4832330 | B | Selectivity index, ratio of IC50 for KDM5A (unknown origin) to IC50 for human KDM4D expressed in Escherichia coli (BL21)DE3 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA4832331 | B | Selectivity index, ratio of IC50 for KDM6A (unknown origin) to IC50 for human KDM4D expressed in Escherichia coli (BL21)DE3 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA4832332 | F | Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4832333 | F | Antiproliferative activity against human SW-620 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4832334 | F | Antiproliferative activity against human SW480 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4832335 | F | Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4832336 | F | Antiproliferative activity against human NCI-H1792 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4832337 | F | Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4832338 | F | Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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