| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4818906 | B | Covalent inhibition of recombinant human GST-tagged BTK (2 to 659 end residues) expressed in baculovirus expression system assessed as inactivation constant using NH2-KKKAPFSWYLPEEG as substrate measured every 2 mins for 2 hrs in presence of ATP by microplate reader assay | Homo sapiens | 15 | assay format | Scientific Literature | ||
| 2. | ALA4818907 | B | Covalent inhibition of recombinant human GST-tagged BTK (2 to 659 end residues) expressed in baculovirus expression system assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substrate measured every 2 mins for 2 hrs in presence of ATP by microplate reader assay | Homo sapiens | 15 | assay format | Scientific Literature | ||
| 3. | ALA4818908 | B | Covalent inhibition of recombinant human GST-tagged BTK (2 to 659 end residues) expressed in baculovirus expression system assessed as Kinact/Ki ratio using NH2-KKKAPFSWYLPEEG as substrate measured every 2 mins for 2 hrs in presence of ATP by microplate reader assay | Homo sapiens | 15 | assay format | Scientific Literature | ||
| 4. | ALA4818909 | B | Inhibition of BTK in C57Bl/6 mouse splenocyte assessed as reduction in anti-IgM-induced CD69 expression incubated for 1 hr followed anti-IgM stimulation and measured after overnight by flow cytometry analysis | Mus musculus | 14 | tissue-based format | Scientific Literature | ||
| 5. | ALA4818910 | B | Inhibition of BTK in Wistar rat whole blood assessed as reduction in anti-IgD-induced B220/CD86+ expression incubated for 1 hr followed anti-IgD stimulation and measured after overnight by flow cytometry analysis | Rattus norvegicus | 14 | tissue-based format | Scientific Literature | ||
| 6. | ALA4818911 | B | Inhibition of recombinant human BTK using KVEKIGEGTYGVVYK as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4818912 | B | Inhibition of recombinant human full length BMX using poly(Glu, Tyr) 4:1 as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA4818913 | B | Inhibition of recombinant human full length LCK using KVEKIGEGTYGVVYK as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA4818914 | B | Inhibition of recombinant human ERBB4 (706 to 991 residues) using poly(Glu, Tyr) 4:1 as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA4818915 | B | Inhibition of recombinant human TEC (174 to end residues) using EFPIYDFLPAKKK as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4818916 | B | Inhibition of recombinant human TXK (256 to end residues) using GEEPLYWSFPAKKK as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4818917 | B | Inhibition of recombinant human FGR (2 to end residues) using poly(Glu, Tyr) 4:1 as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA4818918 | B | Inhibition of recombinant human B-RAF (416 to end residues) using myelin basic protein as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4818919 | B | Inhibition of recombinant human SRC (1 to 530 residues) using GGEEEEYFELVKKKK as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA4818920 | B | Inhibition of recombinant human HCK (230 to 497 residues) using GGMEDIYFEFMGGKKK as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4818921 | B | Inhibition of LCK in human CD4+ T-cells assessed as reduction in anti-CD3/anti-CD28 induced IL-2 secretion at 10 uM incubated for 60 mins followed by anti-CD3/anti-CD28 stimulation and measured after 18 hrs by ELISA | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 17. | ALA4818922 | A | Clearance in Sprague-Dawley rat at 5 mg/kg, po or 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4818923 | A | Volume of distribution at steady state in Sprague-Dawley rat at 5 mg/kg, po or 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4818924 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4818925 | A | Oral bioavailability in Sprague-Dawley rat at 5 mg/kg measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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