| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4822200 | B | Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc level incubated for 2 hrs by ELISA | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 2. | ALA4822201 | B | Potency index, ratio of IC50 of NOG to IC50 of compound for inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc level incubated for 2 hrs by ELISA | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 3. | ALA4822202 | B | Inhibition of recombinant human N-terminal Flag-tagged TET1 (1418 to 2136 residues) expressed in Baculovirus infected Sf9 cells assessed as reduction in 5hmc level incubated for 2 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4822203 | B | Inhibition of recombinant human N-terminal Flag-tagged C-terminal His-tagged TET3 (824 to 1795 residues) expressed in Baculovirus infected Sf9 cells assessed as reduction in 5hmc level incubated for 2 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4822204 | B | Binding affinity to human recombinant TET2 (1099 to 1936) catalytic domain assessed as dissociation constant by micro-scale thermophoresis analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 6. | ALA4822205 | B | Reversible inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as restoration of enzyme activity in presence of alpha-KG at 20 uM incubated for 2 hrs by ELISA | Homo sapiens | 1 | assay format | Scientific Literature |
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