| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4822508 | F | Antiproliferative activity against human EJ138 cells deficit in CYPs assessed as inhibition of cell growth after 96 hrs by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 2. | ALA4822509 | F | Antiproliferative activity against human RT112 cells proficient in CYP1A1 assessed as inhibition of cell growth after 96 hrs by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 3. | ALA4822510 | F | Antiproliferative activity against wild type chinese hamster CHO cells deficit in CYPs assessed as inhibition of cell growth after 96 hrs by MTT assay | Cricetulus griseus | 5 | cell-based format | Scientific Literature | ||
| 4. | ALA4822511 | F | Antiproliferative activity against chinese hamster CHO cells transfected with CYP1A1 assessed as inhibition of cell growth after 96 hrs by MTT assay | Cricetulus griseus | 5 | cell-based format | Scientific Literature | ||
| 5. | ALA4822512 | F | Antiproliferative activity against human EJ138 cells assessed as inhibition of cell growth preincubated for 1 hr with CYP null bactosomes measured after 96 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4822513 | F | Antiproliferative activity against human EJ138 cells assessed as inhibition of cell growth preincubated for 1 hr with human CYP1A1 expressing bactosomes measured after 96 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4822514 | F | Antiproliferative activity against human EJ138 cells assessed as inhibition of cell growth preincubated for 1 hr with human CYP1A2 expressing bactosomes measured after 96 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4822515 | F | Antiproliferative activity against human EJ138 cells assessed as inhibition of cell growth preincubated for 1 hr with human CYP1B1 expressing bactosomes measured after 96 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4822516 | F | Antiproliferative activity against human EJ138 cells assessed as inhibition of cell growth preincubated for 1 hr with human CYP3A4 expressing bactosomes measured after 96 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4822517 | A | Drug metabolism assessed as recombinant human CYP1A1-mediated (3-(chloromethyl)-6-hydroxyindolin-1-yl)(5-methoxy-1H-indol-2-yl)methanone formation at 50 uM incubated for 1 hr in presence of reconstituted protein system by LC-MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4822518 | A | Drug metabolism in Wistar rat liver microsomes assessed as CYP-mediated metabolite M16 formation at 0.5 to 23.5 uM prewarmed for 5 mins followed by NADPH addition and measured after 30 mins by HPLC-fluorescence detector analysis | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 12. | ALA4822519 | A | Drug metabolism in human liver microsomes assessed as CYP-mediated metabolite M16 formation at 0.5 to 23.5 uM prewarmed for 5 mins followed by NADPH addition and measured after 30 mins by HPLC-fluorescence detector analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 13. | ALA4822520 | F | Potentiation factor, ratio of IC50 for antiproliferative activity against human EJ138 cells preincubated for 1 hr with CYP null bactosomes to IC50 for antiproliferative activity against human EJ138 cells preincubated for 1 hr with human CYP1A1 expressing bactosomes | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4822521 | F | Potentiation factor, ratio of IC50 for antiproliferative activity against human EJ138 cells preincubated for 1 hr with CYP null bactosomes to IC50 for antiproliferative activity against human EJ138 cells preincubated for 1 hr with human CYP1A2 expressing bactosomes | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4822522 | F | Potentiation factor, ratio of IC50 for antiproliferative activity against human EJ138 cells preincubated for 1 hr with CYP null bactosomes to IC50 for antiproliferative activity against human EJ138 cells preincubated for 1 hr with human CYP1B1 expressing bactosomes | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4822523 | F | Potentiation factor, ratio of IC50 for antiproliferative activity against human EJ138 cells preincubated for 1 hr with CYP null bactosomes to IC50 for antiproliferative activity against human EJ138 cells preincubated for 1 hr with human CYP3A4 expressing bactosomes | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4822524 | A | Drug metabolism assessed as human CYP1A1 expressed in bactosomes assessed as metabolite M2 with m/z 357.1 formation measured after 1 hr by LC-MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA4822525 | A | Drug metabolism assessed as human CYP1A1 expressed in bactosomes assessed as metabolite M3 with m/z 339.1 formation measured after 1 hr by LC-MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA4822526 | A | Drug metabolism assessed as human CYP1A1 expressed in bactosomes assessed as (3-(chloromethyl)-6-hydroxyindolin-1-yl)(5-methoxy-1H-indol-2-yl)methanone formation measured after 1 hr by LC-MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4822527 | A | Drug metabolism assessed as human CYP1A2 expressed in bactosomes assessed as (3-(chloromethyl)-6-hydroxyindolin-1-yl)(5-methoxy-1H-indol-2-yl)methanone formation measured after 1 hr by LC-MS analysis | Homo sapiens | 1 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!