| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4822790 | B | Inhibition of CES2 in human liver microsomes assessed as reduction in substrate hydrolysis using fluorescein diacetate as substrate preincubated for 3 mins followed by substrate addition and measured after 20 mins by fluorescence analysis | Homo sapiens | 29 | microsome format | Scientific Literature | ||
| 2. | ALA4822791 | B | Non-competitive inhibition of CES2 in human liver microsomes using fluorescein diacetate as substrate by Lineweaver-Burk plot based Michelis-Menten equation analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 3. | ALA4822792 | A | Cytotoxicity against mouse 3T3-L1 cells assessed as reduction in cell viability at <40 uM after 48 hrs by CCK8 assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4822793 | A | Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability at <40 uM after 48 hrs by CCK8 assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4822794 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at <40 uM after 48 hrs by CCK8 assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4822795 | F | Inhibition of adipogenesis in mouse 3T3-L1 cells assessed as reduction in lipid droplet formation at 40 uM incubated with compound for 72 hrs in presence of adipogenesis-inducing agent followed by culturing in normal medium in presence of compound for 48 hrs by Oil red O staining based analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4822796 | F | Inhibition of adipogenesis in mouse 3T3-L1 cells assessed as reduction in lipid droplet formation at 10 uM incubated with compound for 72 hrs in presence of adipogenesis-inducing agent followed by culturing in normal medium in presence of compound for 48 hrs by Oil red O staining based analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4822797 | B | Potency index, ratio of BNPP IC50 to test compound IC50 for Inhibition of CES2 in human liver microsomes assessed as reduction in substrate hydrolysis using fluorescein diacetate as substrate preincubated for 3 mins followed by substrate addition and measured after 20 mins by fluorescence analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 9. | ALA4822798 | B | Potency index, ratio of LPA IC50 to test compound IC50 for Inhibition of CES2 in human liver microsomes assessed as reduction in substrate hydrolysis using fluorescein diacetate as substrate preincubated for 3 mins followed by substrate addition and measured after 20 mins by fluorescence analysis | Homo sapiens | 1 | microsome format | Scientific Literature |
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