| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4824176 | F | In vivo inhibition of SREBP in mouse assessed as reduction in ACC1 mRNA level in liver at 10 mg/kg, ip administered once daily for 4 days by RT-PCR analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 2. | ALA4824177 | F | In vivo inhibition of SREBP in mouse assessed as reduction in FASN mRNA level in liver at 10 mg/kg, ip administered once daily for 4 days by RT-PCR analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 3. | ALA4824178 | F | In vivo inhibition of SREBP in mouse assessed as reduction in SCD1 mRNA level in liver at 10 mg/kg, ip administered once daily for 4 days by RT-PCR analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 4. | ALA4824179 | F | In vivo inhibition of SREBP in mouse assessed as reduction in PCSK9 mRNA level in liver at 10 mg/kg, ip administered once daily for 4 days by RT-PCR analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA4824180 | A | Effect on serum calcium level in mouse assessed as increase in calcium level at 10 mg/kg, ip administered once daily for 4 days by RT-PCR analysis | Mus musculus | 5 | organism-based format | Scientific Literature | ||
| 6. | ALA4824181 | F | Induction of SCAP degradation in mouse liver at 10 mg/kg, ip administered once daily for 4 days by Western blotting analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA4824182 | B | Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells by luciferase reporter assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 8. | ALA4824183 | A | Cytotoxicity against Chinese hamster CHO cells by beta-galactosidase reporter gene assay | Cricetulus griseus | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4824184 | B | Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells assessed as reduction in precursor SREBP protein level at 5 uM after 24 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4824185 | B | Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells assessed as reduction in mature SREBP protein level at 5 uM after 24 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4824186 | B | Inhibition of FLAG-tagged SCAP (unknown origin) expressed in CHO-K1 cells assessed as reduction in SCAP protein level at 5 uM after 24 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4824187 | B | Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells assessed as reduction in precursor SREBP protein level at 1 uM after 24 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4824188 | B | Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells assessed as reduction in mature SREBP protein level at 1 uM after 24 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4824189 | B | Inhibition of FLAG-tagged SCAP (unknown origin) expressed in CHO-K1 cells assessed as reduction in SCAP protein level at 1 uM after 24 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4824190 | B | Inhibition of FLAG-tagged SCAP (unknown origin) expressed in CHO-K1 cells assessed as reduction in SCAP protein level at 1 to 5 uM after 24 hrs in presence of proteasome inhibitor MG132 by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4824191 | T | Toxicity in ob/ob mouse assessed as sick at 10 mg/kg, ip administered 5 times per week for 4 weeks | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 17. | ALA4824192 | T | Toxicity in ob/ob mouse assessed as increase in weight at 10 mg/kg, ip administered 5 times per week for 4 weeks | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4824193 | F | Effect on liver steatosis in ob/ob mouse at 10 mg/kg, ip administered 5 times per week for 4 weeks by HE staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4824194 | F | Reduction in hepatic triglyceride level in ob/ob mouse at 10 mg/kg, ip administered 5 times per week for 4 weeks | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4824195 | F | Reduction in hepatic cholesterol content in ob/ob mouse at 10 mg/kg, ip administered 5 times per week for 4 weeks | Mus musculus | 1 | organism-based format | Scientific Literature |
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