# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4841107 | ADME | Half life in Sprague-Dawley rat at 10 mg/kg, po measured after 48 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4840327 | organism-based format | Scientific Literature | |
2. | ALA4841109 | ADME | Metabolic stability in ICR mouse liver microsomes assessed as parent compound remaining at 0.1 uM incubated for 60 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 6 | ALA4840327 | microsome format | Scientific Literature | |
3. | ALA4841110 | ADME | Metabolic stability in Sprague-Dawley rat plasma assessed as parent compound remaining at 1 uM incubated for 120 mins by LC-MS/MS analysis | Rattus norvegicus | 6 | ALA4840327 | cell-free format | Scientific Literature | |
4. | ALA4841112 | ADME | Cytotoxicity against human L02 cells assessed as cell viability at 100 uM measured after 48 hrs by MTT assay relative to control | Homo sapiens | 1 | ALA4840327 | cell-based format | Scientific Literature | |
5. | ALA4841113 | Binding | Inhibition of human recombinant DPP9 using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by fluorescence based microplate reader assay | Homo sapiens | 18 | ALA4840327 | single protein format | Scientific Literature | |
6. | ALA4841115 | Binding | Inhibition of human recombinant DPP8 using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by fluorescence based microplate reader assay | Homo sapiens | 18 | ALA4840327 | single protein format | Scientific Literature | |
7. | ALA4841116 | Binding | Inhibition of human recombinant DPP4 using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by fluorescence based microplate reader assay | Homo sapiens | 36 | ALA4840327 | single protein format | Scientific Literature | |
8. | ALA4841120 | ADME | Tmax in Sprague-Dawley rat at 10 mg/kg, po measured after 48 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4840327 | organism-based format | Scientific Literature | |
9. | ALA4841122 | ADME | Cmax in Sprague-Dawley rat at 10 mg/kg, po measured after 48 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4840327 | organism-based format | Scientific Literature | |
10. | ALA4841124 | ADME | AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po measured after 48 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4840327 | organism-based format | Scientific Literature | |
11. | ALA4841126 | ADME | Clearance in Sprague-Dawley rat at 10 mg/kg, po measured after 48 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4840327 | organism-based format | Scientific Literature | |
12. | ALA4841128 | Functional | In vivo inhibition of DPP4 in Sprague-Dawley rat plasma at 10 mg/kg, po via gavage using Gly-Pro-AMC as substrate measured after 30 mins relative to control | Rattus norvegicus | 3 | ALA4840327 | organism-based format | Scientific Literature | |
13. | ALA4841129 | Functional | In vivo inhibition of DPP4 in Sprague-Dawley rat plasma at 10 mg/kg, po via gavage using Gly-Pro-AMC as substrate measured after 12 hrs relative to control | Rattus norvegicus | 3 | ALA4840327 | organism-based format | Scientific Literature |