# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4817394 | F | Antiproliferative activity against ALK positive human SR cells | Homo sapiens | 37 | cell-based format | Scientific Literature | ||
2. | ALA4817395 | B | Protac activity at CRBN/ALK in human SR cells assessed as increase in ALK degradation at 500 nM by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
3. | ALA4817397 | B | Protac activity at CRBN/ALK in human SR cells assessed as protein abundance at 5 nM by Western blot analysis (Rvb = 1 No_unit) | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
4. | ALA4817399 | B | Protac activity at CRBN/ALK in human SR cells assessed as induction of ALK degradation by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA4817400 | B | Protac activity at CRBN/ALK in human SR cells assessed as induction of ALK degradation at 0.05 to 500 nM by Western blot analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4817401 | F | Potency index, ratio of ceritinib IC50 to test compound IC50 for antiproliferative activity against ALK positive human SR cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
7. | ALA4817402 | B | Protac activity at CRBN/ALK in human SR cells assessed as increase in ALK degradation at 50 nM in presence of MLN4924/MG132 by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4817403 | B | Inhibition of ALK phosphorylation in human SR cells at 0.5 nM | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA4817404 | B | Inhibition of ALK in human SR cells assessed as reduction in STAT3 phosphorylation at 50 nM | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA4817405 | B | Inhibition of ALK (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
11. | ALA4817406 | B | Inhibition of ALK G1202R mutant (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
12. | ALA4817407 | F | Induction of cell cycle arrest in human SR cells assessed as increase in accumulation at G1/S phase at 100 nM incubated for 24 hrs | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
13. | ALA4817408 | F | Induction of cell cycle arrest in human SR cells assessed as increase in accumulation at S phase at 100 nM incubated for 24 hrs | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
14. | ALA4817409 | A | Cmax in rat at 2 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
15. | ALA4817410 | A | Plasma concentration in rat at 10 mg/kg, po measured after 4 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
16. | ALA4817411 | A | Oral bioavailability in rat at 10 mg/kg | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
17. | ALA4817412 | T | Toxicity in rat at 10 mg/kg, po assessed as adverse effect | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
18. | ALA4817413 | A | Stability in liver microsomes (unknown origin) | Not specified | 1 | microsome format | Scientific Literature | ||
19. | ALA4817415 | B | Protac activity at CRBN/ALK in human SR cells assessed as increase in ALK degradation at 50 nM in presence of MG132 by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA4817416 | B | Protac activity at CRBN/ALK in human SR cells assessed as protein abundance at 0.05 nM by Western blot analysis (Rvb = 1 No_unit) | Homo sapiens | 6 | cell-based format | Scientific Literature |