| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4831149 | F | Growth inhibition of human MDA-MB-468 cells assessed as cell viability measured after 4 days by WST8 assay | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
| 2. | ALA4831150 | F | Growth inhibition of human BT-549 cells assessed as cell viability measured after 4 days by WST8 assay | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
| 3. | ALA4831151 | F | Growth inhibition of human MDA-MB-231 cells assessed as cell viability measured after 4 days by WST8 assay | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
| 4. | ALA4831152 | B | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 at 500 nM incubated for 8 hrs by Western blot analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 5. | ALA4831153 | B | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 at 500 nM measured after 2 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4831154 | B | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 measured after 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4831155 | B | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 pretreated with compound 44 at 500 nM incubated for 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4831156 | B | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 pretreated with thalidomide at 500 nM incubated for 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4831157 | B | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 pretreated with PR171 at 500 nM incubated for 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4831158 | B | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 pretreated with MLN4924 at 500 nM incubated for 8 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4831159 | B | Protac activity at CRBN/CDK1 in human MDA-MB-231 cells assessed as induction of degradation of CDK1 at 0.01 to 2.5 uM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4831160 | B | Protac activity at CRBN/CDK2 in human MDA-MB-231 cells assessed as induction of degradation of CDK2 at 0.01 to 2.5 uM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4831161 | B | Protac activity at CRBN/CDK4 in human MDA-MB-231 cells assessed as induction of degradation of CDK4 at 0.01 to 2.5 uM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4831162 | B | Protac activity at CRBN/CDK5 in human MDA-MB-231 cells assessed as induction of degradation of CDK5 at 0.01 to 2.5 uM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4831163 | B | Protac activity at CRBN/CDK6 in human MDA-MB-231 cells assessed as induction of degradation of CDK6 at 0.01 to 2.5 uM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4831164 | B | Protac activity at CRBN/CDK7 in human MDA-MB-231 cells assessed as induction of degradation of CDK7 at 0.01 to 2.5 uM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4831165 | F | Downregulation of CDK9 mRNA expression in human MDA-MB-231 cells at 0.5 uM incubated for 4 hrs by RNA-seq analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4831166 | F | Downregulation of MCL1 gene expression in human MDA-MB-231 cells at 0.5 uM incubated for 4 hrs by quantitative RT-PCR based gene set enrichment analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4831167 | F | Downregulation of MYC gene expression in human MDA-MB-231 cells at 0.5 uM incubated for 4 hrs by quantitative RT-PCR based gene set enrichment analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4831168 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as apoptotic cells at 10 nM incubated for 48 hrs by Annexin V-FITC/PI analysis (Rvb = 4.85%) | Homo sapiens | 1 | cell-based format | Scientific Literature |
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