# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4831149 | Functional | Growth inhibition of human MDA-MB-468 cells assessed as cell viability measured after 4 days by WST8 assay | Homo sapiens | 44 | ALA4828763 | cell-based format | Scientific Literature | |
2. | ALA4831150 | Functional | Growth inhibition of human BT-549 cells assessed as cell viability measured after 4 days by WST8 assay | Homo sapiens | 44 | ALA4828763 | cell-based format | Scientific Literature | |
3. | ALA4831151 | Functional | Growth inhibition of human MDA-MB-231 cells assessed as cell viability measured after 4 days by WST8 assay | Homo sapiens | 44 | ALA4828763 | cell-based format | Scientific Literature | |
4. | ALA4831152 | Binding | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 at 500 nM incubated for 8 hrs by Western blot analysis | Homo sapiens | 8 | ALA4828763 | cell-based format | Scientific Literature | |
5. | ALA4831153 | Binding | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 at 500 nM measured after 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
6. | ALA4831154 | Binding | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 measured after 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
7. | ALA4831155 | Binding | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 pretreated with compound 44 at 500 nM incubated for 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
8. | ALA4831156 | Binding | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 pretreated with thalidomide at 500 nM incubated for 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
9. | ALA4831157 | Binding | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 pretreated with PR171 at 500 nM incubated for 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
10. | ALA4831158 | Binding | Protac activity at CRBN/CDK9 in human MDA-MB-231 cells assessed as induction of degradation of CDK9 pretreated with MLN4924 at 500 nM incubated for 8 hrs by Western blot analysis | Homo sapiens | 2 | ALA4828763 | cell-based format | Scientific Literature | |
11. | ALA4831159 | Binding | Protac activity at CRBN/CDK1 in human MDA-MB-231 cells assessed as induction of degradation of CDK1 at 0.01 to 2.5 uM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
12. | ALA4831160 | Binding | Protac activity at CRBN/CDK2 in human MDA-MB-231 cells assessed as induction of degradation of CDK2 at 0.01 to 2.5 uM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
13. | ALA4831161 | Binding | Protac activity at CRBN/CDK4 in human MDA-MB-231 cells assessed as induction of degradation of CDK4 at 0.01 to 2.5 uM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
14. | ALA4831162 | Binding | Protac activity at CRBN/CDK5 in human MDA-MB-231 cells assessed as induction of degradation of CDK5 at 0.01 to 2.5 uM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
15. | ALA4831163 | Binding | Protac activity at CRBN/CDK6 in human MDA-MB-231 cells assessed as induction of degradation of CDK6 at 0.01 to 2.5 uM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
16. | ALA4831164 | Binding | Protac activity at CRBN/CDK7 in human MDA-MB-231 cells assessed as induction of degradation of CDK7 at 0.01 to 2.5 uM incubated for 4 to 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
17. | ALA4831165 | Functional | Downregulation of CDK9 mRNA expression in human MDA-MB-231 cells at 0.5 uM incubated for 4 hrs by RNA-seq analysis | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
18. | ALA4831166 | Functional | Downregulation of MCL1 gene expression in human MDA-MB-231 cells at 0.5 uM incubated for 4 hrs by quantitative RT-PCR based gene set enrichment analysis relative to control | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
19. | ALA4831167 | Functional | Downregulation of MYC gene expression in human MDA-MB-231 cells at 0.5 uM incubated for 4 hrs by quantitative RT-PCR based gene set enrichment analysis relative to control | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature | |
20. | ALA4831168 | Functional | Induction of apoptosis in human MDA-MB-231 cells assessed as apoptotic cells at 10 nM incubated for 48 hrs by Annexin V-FITC/PI analysis (Rvb = 4.85%) | Homo sapiens | 1 | ALA4828763 | cell-based format | Scientific Literature |