Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as upregulation of CD4+ CD25+ cell frequency at 1 uM measured after 72 hrs by flow cytometry analysis
Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as upregulation of Foxp3 mRNA expression at 1 uM measured after 72 hrs by Q-PCR analysis
Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as number of Treg cells at 3 uM measured after 72 hrs by flow cytometry analysis (Rvb = 24 %)
Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as number of Treg cells at 0.3 uM measured after 72 hrs by flow cytometry analysis (Rvb = 24 %)
Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as number of Treg cells at 1 uM measured after 72 hrs by flow cytometry analysis (Rvb = 24 %)
Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as upregulation of Foxp3 mRNA expression at 0.3 to 3 uM measured after 72 hrs by Q-PCR analysis
Induction of cell differentiation in anti-CD3/CD28 stimulated naive T-cells assessed as upregulation of IL-10 mRNA expression at 0.3 to 3 uM measured after 72 hrs by Q-PCR analysis
Antiinflammatory activity in DSS-induced ulcerative colitis mouse model assessed as reduction in DAI score at 28 to 56 mg/kg, po administered for 10 consecutive days
Antiinflammatory activity in DSS-induced ulcerative colitis mouse model assessed as rescue of colon length shortening at 28 to 56 mg/kg, po administered for 10 consecutive days
Antiinflammatory activity in DSS-induced ulcerative colitis mouse model assessed as reduction in MPO activity at 28 to 56 mg/kg, po administered for 10 consecutive days
Antiinflammatory activity in DSS-induced ulcerative colitis mouse model assessed as protection against colon destruction at 28 to 56 mg/kg, po administered for 10 consecutive days by HE staining based histopathological analysis
Antiinflammatory activity in DSS-induced ulcerative colitis mouse model assessed as protection against inflammation of colons at 28 to 56 mg/kg, po administered for 10 consecutive days by HE staining based histopathological analysis
Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as number of Treg cells in colonic lamina proprias at 28 mg/kg, po administered for 10 consecutive days by flow cytometry analysis (Rvb= 7.97%)
Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as number of Treg cells in colonic lamina proprias at 56 mg/kg, po administered for 10 consecutive days by flow cytometry analysis (Rvb= 7.97%)
Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as number of Treg cells in mesenteric lymph nodes at 28 mg/kg, po administered for 10 consecutive days by flow cytometry analysis (Rvb= 7.52%)
Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as number of Treg cells in mesenteric lymph nodes at 56 mg/kg, po administered for 10 consecutive days by flow cytometry analysis (Rvb= 7.52%)
Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as number of Treg cells in spleens at 28 mg/kg, po administered for 10 consecutive days by flow cytometry analysis (Rvb= 6.49%)
Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as number of Treg cells in spleens at 56 mg/kg, po administered for 10 consecutive days by flow cytometry analysis (Rvb= 6.49%)
Induction of Treg cell differentiation in DSS- induced ulcerative colitis mouse model assessed as increase in Foxp3 mRNA level at 28 to 56 mg/kg, po administered for 10 consecutive days by Q-PCR analysis