# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4827438 | A | AUC (0 to infinity) in Wistar Han rat at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4825709 | organism-based format | Scientific Literature | |
2. | ALA4827439 | A | Half life in Wistar Han rat at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4825709 | organism-based format | Scientific Literature | |
3. | ALA4827440 | A | Clearance in Wistar Han rat at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4825709 | organism-based format | Scientific Literature | |
4. | ALA4827441 | B | Displacement of Alexa Fluor 647 labelled ligand from 6His-tagged BRD4 BD1/BD2 Y390A mutant (1 to 477 residue) (unknown origin) measured after 30 mins by TR-FRET assay | Homo sapiens | 43 | ALA4825709 | single protein format | Scientific Literature | |
5. | ALA4827442 | B | Displacement of Alexa Fluor 647 labelled ligand from 6His-tagged BRD4 BD2/BD1 Y97A mutant (1 to 477 residue) (unknown origin) measured after 30 mins by TR-FRET assay | Homo sapiens | 43 | ALA4825709 | single protein format | Scientific Literature | |
6. | ALA4827443 | B | Selectivity ratio of IC50 for 6His-tagged BRD4 BD1/BD2 Y390A mutant (1 to 477 residue) (unknown origin) to IC50 for 6His-tagged BRD4 BD2/BD1 Y97A mutant (1 to 477 residue) (unknown origin) | Homo sapiens | 43 | ALA4825709 | assay format | Scientific Literature | |
7. | ALA4827450 | P | Lipophilicity, logD of compound at pH 7.4 by HPLC analysis | 41 | ALA4825709 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4827451 | A | Apparent permeability of compound at pH 7.4 by artificial membrane permeability assay | 43 | ALA4825709 | assay format | Scientific Literature | ||
9. | ALA4827454 | P | Solubility of compound in pH 7.4 by charged aerosol detection method | 3 | ALA4825709 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4827455 | P | Solubility of the compound in pH 6.5 FaSSIF at 125 ug/ml incubated for 16 hrs by HPLC analysis | 14 | ALA4825709 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4827456 | F | Inhibition of LPS-induced MCP1 production in human whole blood preincubated for 30 mins followed by LPS addition measured after 24 hrs by flow cytometry | Homo sapiens | 1 | ALA4825709 | tissue-based format | Scientific Literature | |
12. | ALA4827457 | A | Intrinsic clearance in rat hepatocytes at 0.5 uM measured after 60 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4825709 | cell-based format | Scientific Literature | |
13. | ALA4827458 | A | Intrinsic clearance in human hepatocytes at 0.5 uM measured after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4825709 | cell-based format | Scientific Literature | |
14. | ALA4827459 | A | Intrinsic clearance in dog hepatocytes at 0.5 uM measured after 120 mins by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA4825709 | cell-based format | Scientific Literature | |
15. | ALA4827460 | A | Volume of distribution at steady state in Wistar Han rat at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4825709 | organism-based format | Scientific Literature | |
16. | ALA4827461 | A | Cmax in Wistar Han rat at 3 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4825709 | organism-based format | Scientific Literature | |
17. | ALA4827462 | A | Tmax in Wistar Han rat at 3 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4825709 | organism-based format | Scientific Literature | |
18. | ALA4827463 | A | AUC (0 to infinity) in Wistar Han rat at 3 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4825709 | organism-based format | Scientific Literature | |
19. | ALA4827464 | A | Oral bioavailability in Wistar Han rat at 3 mg/kg measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4825709 | organism-based format | Scientific Literature | |
20. | ALA4827465 | B | Inhibition of human BRD2 BD1 (K71 to N194 residues) expressed in bacterial expression system at 10 uM by DiscoverX assay relative to control | Homo sapiens | 1 | ALA4825709 | assay format | Scientific Literature |