# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4841939 | F | Antiviral activity against HIV-1 infected in MT4 cells assessed as reduction in virus-induced cytopathic effect preincubated for 1 hr followed by viral infection and measured after 5 days by XTT assay | Human immunodeficiency virus 1 | 51 | ALA4840358 | organism-based format | Scientific Literature | |
2. | ALA4841940 | A | Cytotoxicity against in human MT4 cells after 5 days by XTT assay | Homo sapiens | 51 | ALA4840358 | cell-based format | Scientific Literature | |
3. | ALA4841945 | A | Stability of compound in pooled human plasma assessed as half life at 5 uM measured for 120 to 240 mins by ECHO-MS analysis | Homo sapiens | 3 | ALA4840358 | cell-free format | Scientific Literature | |
4. | ALA4841946 | A | Stability of compound in pooled human plasma assessed as compound remaining at 5 uM measured for 120 to 240 mins by ECHO-MS analysis | Homo sapiens | 6 | ALA4840358 | cell-free format | Scientific Literature | |
5. | ALA4841947 | A | Stability of compound in pooled human hepatic microsomes assessed as compound remaining at 5 uM measured upto 30 mins in presence of NADPH by ECHO-MS analysis | Homo sapiens | 6 | ALA4840358 | microsome format | Scientific Literature | |
6. | ALA4841950 | B | Substrate activity at cathepsin A (unknown origin) at 30 uM after 30 mins | Homo sapiens | 9 | ALA4840358 | single protein format | Scientific Literature | |
7. | ALA4841951 | A | Drug uptake in human CCRF-CEM cells assessed as intracellular intact prodrug level at 50 uM after 45 mins by ECHO-MS analysis | Homo sapiens | 9 | ALA4840358 | cell-based format | Scientific Literature | |
8. | ALA4841952 | A | Drug uptake in human CCRF-CEM cells assessed as released tenofovir level at 50 uM after 45 mins by ECHO-MS analysis | Homo sapiens | 9 | ALA4840358 | cell-based format | Scientific Literature |