| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4824099 | B | Agonist activity at human TRPA1 expressed in HEK cells assessed as increase in menthol-induced intracellular calcium level incubated for 2 hrs by FLIPR assay | Homo sapiens | 4 | ALA4823260 | cell-based format | Scientific Literature | |
| 2. | ALA4824100 | B | Agonist activity at human TRPV4 expressed in HEK cells assessed as increase in GSK1016790A-induced intracellular calcium level measured after 1 hr by FLIPR assay | Homo sapiens | 4 | ALA4823260 | cell-based format | Scientific Literature | |
| 3. | ALA4824101 | B | Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in capsaicin-induced intracellular calcium level measured after 1 hr by FLIPR assay | Homo sapiens | 4 | ALA4823260 | cell-based format | Scientific Literature | |
| 4. | ALA4824102 | B | Agonist activity at human TRPM8 expressed in HEK cells assessed as increase in menthol-induced intracellular calcium level measured after 1 hr by FLIPR assay | Homo sapiens | 4 | ALA4823260 | cell-based format | Scientific Literature | |
| 5. | ALA4824103 | A | Efflux ratio of apparent permeability across basolateral to apical over apical to basolateral membrane in human Caco-2 cells incubated for 30 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4823260 | cell-based format | Scientific Literature | |
| 6. | ALA4824104 | A | Apparent permeability across apical to basolateral membrane in human Caco-2 cells incubated for 30 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4823260 | cell-based format | Scientific Literature | |
| 7. | ALA4824105 | B | Agonist activity at human TRPM5 expressed in CHO-K1 cells maintained at 80 mV final holding potential by syncroPatch assay | Homo sapiens | 72 | ALA4823260 | cell-based format | Scientific Literature | |
| 8. | ALA4824107 | B | Agonist activity at mouse TRPM5 expressed in CHO-K1 cells maintained at 80 mV final holding potential by syncroPatch assay | Mus musculus | 4 | ALA4823260 | cell-based format | Scientific Literature | |
| 9. | ALA4824108 | A | Intrinsic clearance in human liver microsomes assessed per mg protein incubated up to 30 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 19 | ALA4823260 | microsome format | Scientific Literature | |
| 10. | ALA4824109 | A | Intrinsic clearance in mouse liver microsomes assessed per mg protein incubated up to 30 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 19 | ALA4823260 | microsome format | Scientific Literature | |
| 11. | ALA4824110 | P | Solubility of the compound in phospahte-buffered saline buffer at pH 7.4 incubated for 2 hrs by HPLC/UV analysis | 4 | ALA4823260 | small-molecule physicochemical format | Scientific Literature | ||
| 12. | ALA4824111 | B | Agonist activity at human TRPM4 expressed in CHO cells assessed as increase in A23187-induced intracellular calcium level by FLIPR assay | Homo sapiens | 4 | ALA4823260 | cell-based format | Scientific Literature | |
| 13. | ALA4824112 | A | Protein binding in human plasma assessed as unbound fraction measured after 5 hrs by equilibrium dialysis based HPLC/UPLC-MS/MS analysis | Homo sapiens | 4 | ALA4823260 | cell-free format | Scientific Literature | |
| 14. | ALA4824116 | A | Protein binding in mouse plasma assessed as unbound fraction measured after 5 hrs by equilibrium dialysis based HPLC/UPLC-MS/MS analysis | Mus musculus | 2 | ALA4823260 | cell-free format | Scientific Literature | |
| 15. | ALA4824117 | A | Observed clearance in CD-1 mouse at 1 mg/kg, iv measured up to 24 hrs | Mus musculus | 1 | ALA4823260 | organism-based format | Scientific Literature | |
| 16. | ALA4824118 | A | Clast in CD-1 mouse at 1 mg/kg, iv measured up to 24 hrs | Mus musculus | 1 | ALA4823260 | organism-based format | Scientific Literature | |
| 17. | ALA4824119 | A | Volume of distribution at steady state in CD-1 mouse at 1 mg/kg, iv measured up to 24 hrs | Mus musculus | 1 | ALA4823260 | organism-based format | Scientific Literature | |
| 18. | ALA4824120 | A | Half life in CD-1 mouse at 1 mg/kg, iv measured up to 24 hrs | Mus musculus | 1 | ALA4823260 | organism-based format | Scientific Literature | |
| 19. | ALA4824121 | A | AUClast in CD-1 mouse at 1 mg/kg, iv measured up to 24 hrs | Mus musculus | 1 | ALA4823260 | organism-based format | Scientific Literature | |
| 20. | ALA4824122 | A | Clast in CD-1 mouse at 10 mg/kg, po measured up to 24 hrs | Mus musculus | 1 | ALA4823260 | organism-based format | Scientific Literature |
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