#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4836402	B	Inhibition of human liver mitochondrial KMO assessed as reduction in 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis	Homo sapiens	17		mitochondrion format	Scientific Literature
2.	ALA4836403	A	Metabolic stability in human liver microsomes assessed as intrinsic clearance incubated for 30 mins in presence of NADPH measured per mg protein	Homo sapiens	17		microsome format	Scientific Literature
3.	ALA4836404	A	Metabolic stability in rat liver microsomes assessed as intrinsic clearance incubated for 30 mins in presence of NADPH measured per mg protein	Rattus norvegicus	17		microsome format	Scientific Literature
4.	ALA4836405	P	Glutathione reactivity assessed as dansylatedGSH-compound conjugate formation in presence of human liver microsomes by fluorescence detector based HPLC analysis		17		microsome format	Scientific Literature
5.	ALA4836414	A	Plasma concentration in cynomolgus monkey at 5 mg/kg, po measured after 2 hrs of administration	Macaca fascicularis	2		organism-based format	Scientific Literature
6.	ALA4836415	A	Drug uptake in cynomolgus monkey striatum at 5 mg/kg, po measured after 2 hrs of administration	Macaca fascicularis	2		organism-based format	Scientific Literature
7.	ALA4836416	A	Ratio of drug level in cynomolgus monkey striatum to plasma at 5 mg/kg, po measured after 2 hrs of administration	Macaca fascicularis	2		organism-based format	Scientific Literature
8.	ALA4836417	F	Neuroprotective activity in R6/2 transgenic mouse model assessed as reduction in 3-HK level in striatum at 25 to 100 mg/kg, po measured after 1 hr	Mus musculus	1		organism-based format	Scientific Literature
9.	ALA4836418	F	Neuroprotective activity in R6/2 transgenic mouse model assessed as increase in KYNA level in striatum at 25 to 100 mg/kg, po measured after 1 hr relative to control	Mus musculus	1		organism-based format	Scientific Literature
10.	ALA4836419	F	Neuroprotective activity in R6/2 transgenic mouse model assessed as reduction in 3-HK level in striatum at 100 mg/kg, po measured after 24 hrs	Mus musculus	1		organism-based format	Scientific Literature
11.	ALA4836423	A	Clearance in cynomolgus monkey at 0.482 mg/kg, iv	Macaca fascicularis	1		organism-based format	Scientific Literature
12.	ALA4836424	A	Half life in cynomolgus monkey plasma at 0.482 mg/kg, iv	Macaca fascicularis	1		organism-based format	Scientific Literature
13.	ALA4836425	A	Oral bioavailability in cynomolgus monkey at 5 mg/kg	Macaca fascicularis	1		organism-based format	Scientific Literature
14.	ALA4836426	A	Protein binding in cynomolgus monkey striatum at 5 mg/kg, po measured after 2 hrs	Macaca fascicularis	1		organism-based format	Scientific Literature