#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4836402	Binding	Inhibition of human liver mitochondrial KMO assessed as reduction in 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis	Homo sapiens	17	ALA4834453	mitochondrion format	Scientific Literature
2.	ALA4836403	ADME	Metabolic stability in human liver microsomes assessed as intrinsic clearance incubated for 30 mins in presence of NADPH measured per mg protein	Homo sapiens	17	ALA4834453	microsome format	Scientific Literature
3.	ALA4836404	ADME	Metabolic stability in rat liver microsomes assessed as intrinsic clearance incubated for 30 mins in presence of NADPH measured per mg protein	Rattus norvegicus	17	ALA4834453	microsome format	Scientific Literature
4.	ALA4836405	Physicochemical	Glutathione reactivity assessed as dansylatedGSH-compound conjugate formation in presence of human liver microsomes by fluorescence detector based HPLC analysis		17	ALA4834453	microsome format	Scientific Literature
5.	ALA4836414	ADME	Plasma concentration in cynomolgus monkey at 5 mg/kg, po measured after 2 hrs of administration	Macaca fascicularis	2	ALA4834453	organism-based format	Scientific Literature
6.	ALA4836415	ADME	Drug uptake in cynomolgus monkey striatum at 5 mg/kg, po measured after 2 hrs of administration	Macaca fascicularis	2	ALA4834453	organism-based format	Scientific Literature
7.	ALA4836416	ADME	Ratio of drug level in cynomolgus monkey striatum to plasma at 5 mg/kg, po measured after 2 hrs of administration	Macaca fascicularis	2	ALA4834453	organism-based format	Scientific Literature
8.	ALA4836417	Functional	Neuroprotective activity in R6/2 transgenic mouse model assessed as reduction in 3-HK level in striatum at 25 to 100 mg/kg, po measured after 1 hr	Mus musculus	1	ALA4834453	organism-based format	Scientific Literature
9.	ALA4836418	Functional	Neuroprotective activity in R6/2 transgenic mouse model assessed as increase in KYNA level in striatum at 25 to 100 mg/kg, po measured after 1 hr relative to control	Mus musculus	1	ALA4834453	organism-based format	Scientific Literature
10.	ALA4836419	Functional	Neuroprotective activity in R6/2 transgenic mouse model assessed as reduction in 3-HK level in striatum at 100 mg/kg, po measured after 24 hrs	Mus musculus	1	ALA4834453	organism-based format	Scientific Literature
11.	ALA4836423	ADME	Clearance in cynomolgus monkey at 0.482 mg/kg, iv	Macaca fascicularis	1	ALA4834453	organism-based format	Scientific Literature
12.	ALA4836424	ADME	Half life in cynomolgus monkey plasma at 0.482 mg/kg, iv	Macaca fascicularis	1	ALA4834453	organism-based format	Scientific Literature
13.	ALA4836425	ADME	Oral bioavailability in cynomolgus monkey at 5 mg/kg	Macaca fascicularis	1	ALA4834453	organism-based format	Scientific Literature
14.	ALA4836426	ADME	Protein binding in cynomolgus monkey striatum at 5 mg/kg, po measured after 2 hrs	Macaca fascicularis	1	ALA4834453	organism-based format	Scientific Literature