# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4829311 | F | Antibiotic adjuvant activity against meropenem-treated NDM-producing carbapenem resistant Klebsiella pneumoniae infected in BALB/c mouse sepsis model assessed as survival rate at 10 mg/kg, ip in the presence of meropenem measured after 7 days | Klebsiella pneumoniae | 1 | organism-based format | Scientific Literature | ||
2. | ALA4829312 | F | Antibiotic adjuvant activity against meropenem-treated NDM-producing carbapenem resistant Klebsiella pneumoniae infected in BALB/c mouse sepsis model assessed as mouse rescue at 10 mg/kg, ip in the presence of meropenem measured after 48 hrs | Klebsiella pneumoniae | 2 | organism-based format | Scientific Literature | ||
3. | ALA4829313 | F | Antibacterial activity against NDM-producing carbapenem resistant Klebsiella pneumoniae infected in BALB/c mouse sepsis model assessed as animal survival at 10 mg/kg, ip measured after 48 hrs | Klebsiella pneumoniae | 2 | organism-based format | Scientific Literature | ||
4. | ALA4829314 | F | Antibacterial activity against IMP-4 producing Escherichia coli DH5 alpha assessed as bacterial growth at 8 ug/ml incubated for 16 to 20 hrs by CLSI based microdilution method | Escherichia coli | 2 | organism-based format | Scientific Literature | ||
5. | ALA4829315 | B | Zinc chelation-dependent inhibition of NDM-1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using meropenem as substrate preincubated with enzyme for 5 to 10 mins followed by substrate addition | 8 | assay format | Scientific Literature | |||
6. | ALA4829316 | B | Zinc chelation-dependent inhibition of VIM-2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using nitrocefin as substrate preincubated with enzyme for 5 to 10 mins followed by substrate addition | 8 | assay format | Scientific Literature | |||
7. | ALA4829317 | B | Zinc chelation-dependent inhibition of IMP-4 (unknown origin) expressed in Escherichia coli BL21 (DE3) using imipenem as substrate preincubated with enzyme for 5 to 10 mins followed by substrate addition | 8 | assay format | Scientific Literature | |||
8. | ALA4829318 | F | Antibacterial activity against NDM-1 producing Escherichia coli DH5alpha assessed as decrease in bacterial growth incubated for 16 to 20 hrs by CLSI based microdilution method | Escherichia coli | 5 | organism-based format | Scientific Literature | ||
9. | ALA4829319 | F | Antibacterial activity against IMP-4 producing Escherichia coli DH5alpha assessed as decrease in bacterial growth incubated for 16 to 20 hrs by CLSI based microdilution method | Escherichia coli | 5 | organism-based format | Scientific Literature | ||
10. | ALA4829320 | F | Antibacterial activity against VIM-1 producing Escherichia coli DH5alpha assessed as decrease in bacterial growth incubated for 16 to 20 hrs by CLSI based microdilution method | Escherichia coli | 5 | organism-based format | Scientific Literature | ||
11. | ALA4829321 | F | Antibacterial activity against MBL producing Enterobacter cloacae isolates assessed as inhibition of bacterial growth at 64 ug/ml incubated for 16 to 20 hrs by CLSI based microdilution method | Enterobacter cloacae | 2 | organism-based format | Scientific Literature | ||
12. | ALA4829322 | F | Antibacterial activity against MBL producing Escherichia coli isolates assessed as inhibition of bacterial growth at 64 ug/ml incubated for 16 to 20 hrs by CLSI based microdilution method | Escherichia coli | 2 | organism-based format | Scientific Literature | ||
13. | ALA4829323 | F | Antibacterial activity against MBL producing Klebsiella pneumoniae isolates assessed as inhibition of bacterial growth at 64 ug/ml incubated for 16 to 20 hrs by CLSI based microdilution method | Klebsiella pneumoniae | 2 | organism-based format | Scientific Literature | ||
14. | ALA4829324 | F | Antibacterial activity against MBL producing Klebsiella oxytoca isolates assessed as inhibition of bacterial growth at 64 ug/ml incubated for 16 to 20 hrs by CLSI based microdilution method | Klebsiella oxytoca | 2 | organism-based format | Scientific Literature | ||
15. | ALA4829325 | F | Antibacterial activity against MBL producing Citrobacter freundii isolates assessed as inhibition of bacterial growth at 64 ug/ml incubated for 16 to 20 hrs by CLSI based microdilution method | Citrobacter freundii | 2 | organism-based format | Scientific Literature | ||
16. | ALA4829326 | F | Antibacterial activity against MBL producing Enterobacter hormaechei isolates assessed as inhibition of bacterial growth at 64 ug/ml incubated for 16 to 20 hrs by CLSI based microdilution method | Enterobacter hormaechei | 2 | organism-based format | Scientific Literature | ||
17. | ALA4829327 | F | Antibacterial activity against MBL producing Pseudomonas aeruginosa isolates assessed as inhibition of bacterial growth at 64 ug/ml incubated for 16 to 20 hrs by CLSI based microdilution method | Pseudomonas aeruginosa | 2 | organism-based format | Scientific Literature | ||
18. | ALA4829328 | F | Antibiotic adjuvant activity against meropenem-treated VIM-1 producing Escherichia coli DH5 alpha assessed as bacterial growth at 8 ug/ml incubated for 16 to 20 hrs in the presence of meropenem and 100 uM zinc sulfate by CLSI based microdilution method | Escherichia coli | 2 | organism-based format | Scientific Literature | ||
19. | ALA4829329 | F | Antibiotic adjuvant activity against meropenem-treated VIM-1 producing Escherichia coli DH5 alpha assessed as inhibition of bacterial growth at 8 ug/ml incubated for 16 to 20 hrs in the presence of meropenem and 1 to 10 uM zinc sulfate by CLSI based microdilution method | Escherichia coli | 2 | organism-based format | Scientific Literature | ||
20. | ALA4829330 | F | Antibiotic adjuvant activity against meropenem-treated VIM-1 producing Escherichia coli DH5 alpha assessed as bacterial growth at 8 ug/ml incubated for 16 to 20 hrs in the presence of meropenem by CLSI based microdilution method | Escherichia coli | 2 | organism-based format | Scientific Literature |