# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA846495 | B | Ratio of binding affinity for NK1 receptor in guinea pig to that of rat was determined; ND=No data | 2 | ALA1159145 | single protein format | Scientific Literature | ||
2. | ALA812239 | B | Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand | Cavia porcellus | 16 | ALA1159145 | tissue-based format | Scientific Literature | |
3. | ALA813323 | B | Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand | 15 | ALA1159145 | cell membrane format | Scientific Literature | ||
4. | ALA813646 | B | Ability to displace the binding of [125I]iodohistidyl-NKA to Tachykinin receptor 2 in hamster urinary bladder membranes was determined. | Cricetulus griseus | 13 | ALA1159145 | cell membrane format | Scientific Literature | |
5. | ALA815573 | B | Ability to displace the binding of [3H]-Senktide to Tachykinin receptor 3 in rat cerebral cortex membranes was determined. | 13 | ALA1159145 | cell membrane format | Scientific Literature | ||
6. | ALA4428507 | B | Inhibition of CRT CVIET haplotype mutant in Plasmodium falciparum K1 isolate MRA-159 infected in erythrocytes assessed as chloroquine-coumarin probe accumulation at 10 uM after 10 hrs by Hoechst 33342 staining based flow cytometry (Rvb = 35.57 +/- 3.84%) | Plasmodium falciparum K1 | 38 | ALA4428038 | cell-based format | Scientific Literature | |
7. | ALA4428509 | F | Potentiation of chloroquine-induced antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 isolate MRA-102 assessed as reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum | 11 | ALA4428038 | organism-based format | Scientific Literature | |
8. | ALA4428510 | F | Potentiation of chloroquine-induced antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 isolate MRA-155 assessed as reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum | 11 | ALA4428038 | organism-based format | Scientific Literature | |
9. | ALA4428511 | B | Inhibition of CRT SVMNT haplotype mutant in intermediate chloroquine-resistant Plasmodium falciparum 7G8 isolate MRA-154 t assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum 7G8 | 11 | ALA4428038 | assay format | Scientific Literature | |
10. | ALA4428512 | B | Inhibition of CRT CVIET haplotype mutant in chloroquine-resistant Plasmodium falciparum K1 isolate MRA-159 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum K1 | 11 | ALA4428038 | assay format | Scientific Literature | |
11. | ALA4428513 | B | Inhibition of CRT K76T mutant in chloroquine-resistant Plasmodium falciparum Dd2 isolate MRA-156 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum Dd2 | 11 | ALA4428038 | single protein format | Scientific Literature | |
12. | ALA4428514 | B | Inhibition of CRT K76T mutant in chloroquine/artemisinin-resistant Plasmodium falciparum ARS233 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum | 11 | ALA4428038 | single protein format | Scientific Literature | |
13. | ALA4428515 | B | Inhibition of CRT K76T mutant in chloroquine/artemisinin-resistant Plasmodium falciparum ARS272 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum | 11 | ALA4428038 | single protein format | Scientific Literature | |
14. | ALA4428516 | B | Inhibition of CRT K76T mutant in chloroquine-resistant Plasmodium falciparum NHP4559 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum | 11 | ALA4428038 | single protein format | Scientific Literature | |
15. | ALA4428517 | B | Inhibition of CRT K76T mutant in chloroquine/artemisinin-resistant Plasmodium falciparum NHP4773 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum | 11 | ALA4428038 | single protein format | Scientific Literature | |
16. | ALA4428518 | F | Intrinsic antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 isolate MRA-102 assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature | |
17. | ALA4428519 | F | Intrinsic antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 isolate MRA-155 assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature | |
18. | ALA4428520 | F | Intrinsic antimalarial activity against intermediate chloroquine-resistant Plasmodium falciparum 7G8 isolate MRA-154 harboring CRT SVMNT haplotype mutant assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature | |
19. | ALA4428521 | F | Intrinsic antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 isolate MRA-159 harboring CRT CVIET haplotype mutant assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature | |
20. | ALA4428522 | F | Intrinsic antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 isolate MRA-156 harboring CRT K76T mutant assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature |