# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4828937 | Functional | Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay | Homo sapiens | 5 | ALA4828709 | cell-based format | Scientific Literature | |
2. | ALA4828938 | Functional | Antiproliferative activity against human SH-SY5Y cells harboring ALK F1174L mutant assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay | Homo sapiens | 5 | ALA4828709 | cell-based format | Scientific Literature | |
3. | ALA4828939 | Binding | Inhibition of recombinant human C-terminal His/FLAG-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using Ac-peptide-AMC as substrate at 10 nM preincubated for 15 mins followed by addition of substrate and trypsin measured by flourescence assay | Homo sapiens | 44 | ALA4828709 | cell-based format | Scientific Literature | |
4. | ALA4828940 | Binding | Inhibition of recombinant human C-terminal His/FLAG-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using Ac-peptide-AMC as substrate at 100 nM preincubated for 15 mins followed by addition of substrate and trypsin measured by flourescence assay | Homo sapiens | 44 | ALA4828709 | cell-based format | Scientific Literature | |
5. | ALA4828941 | Binding | Inhibition of ALK (unknown origin) at 10 nM preincubated for 10 mins followed by addition of substrate and ATP for 25 mins by caliper EZ reader method | Homo sapiens | 44 | ALA4828709 | single protein format | Scientific Literature | |
6. | ALA4828942 | Binding | Inhibition of ALK (unknown origin) at 100 nM preincubated for 10 mins followed by addition of substrate and ATP for 25 mins by caliper EZ reader method | Homo sapiens | 44 | ALA4828709 | single protein format | Scientific Literature | |
7. | ALA4828943 | Binding | Inhibition of recombinant human C-terminal His/FLAG-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using Ac-peptide-AMC as substrate preincubated for 15 mins followed by addition of substrate and trypsin measured by flourescence assay | Homo sapiens | 6 | ALA4828709 | cell-based format | Scientific Literature | |
8. | ALA4828944 | Binding | Inhibition of HDAC2 (unknown origin) | Homo sapiens | 6 | ALA4828709 | single protein format | Scientific Literature | |
9. | ALA4828945 | Binding | Inhibition of HDAC6 (unknown origin) | Homo sapiens | 6 | ALA4828709 | single protein format | Scientific Literature | |
10. | ALA4828946 | Binding | Inhibition of ALK (unknown origin) preincubated for 10 mins followed by addition of substrate and ATP for 25 mins by caliper EZ reader method | Homo sapiens | 6 | ALA4828709 | single protein format | Scientific Literature | |
11. | ALA4828947 | Binding | Inhibition of ALK L1196M mutant (unknown origin) | Homo sapiens | 6 | ALA4828709 | single protein format | Scientific Literature | |
12. | ALA4828948 | Binding | Inhibition of ALK G1202R mutant (unknown origin) | Homo sapiens | 6 | ALA4828709 | single protein format | Scientific Literature | |
13. | ALA4828949 | Functional | Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay | Homo sapiens | 5 | ALA4828709 | cell-based format | Scientific Literature | |
14. | ALA4828950 | Functional | Antiproliferative activity against human SKNBE2 cells harboring wild type ALK assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay | Homo sapiens | 5 | ALA4828709 | cell-based format | Scientific Literature | |
15. | ALA4828951 | Functional | Antiproliferative activity against human NCI-H2228 cells harboring EML4/ALK L1196M mutant assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay | Homo sapiens | 5 | ALA4828709 | cell-based format | Scientific Literature | |
16. | ALA4828952 | Functional | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay | Homo sapiens | 5 | ALA4828709 | cell-based format | Scientific Literature | |
17. | ALA4828953 | Functional | Inhibition of colony formation in human MDA-MB-231 cells at 0.1 to 0.4 uM incubated for 3 days followed by incubation in drug-free medium for 12 days by crystal violet staining based assay | Homo sapiens | 1 | ALA4828709 | cell-based format | Scientific Literature | |
18. | ALA4828954 | Functional | Inhibition of colony formation in human SH-SY5Y cells at 0.1 to 0.4 uM incubated for 3 days followed by incubation in drug-free medium for 12 days by crystal violet staining based assay | Homo sapiens | 1 | ALA4828709 | cell-based format | Scientific Literature | |
19. | ALA4828955 | Functional | Antimigratory activity against human MDA-MB-231 cells assessed as wound closure at 0.4 uM measured after 48 hrs by cell scratch assay (Rvb = 30.3%) | Homo sapiens | 1 | ALA4828709 | cell-based format | Scientific Literature | |
20. | ALA4828956 | Functional | Antimigratory activity against human SH-SY5Y cells assessed as wound closure at 0.4 uM measured after 48 hrs by cell scratch assay (Rvb = 15.1%) | Homo sapiens | 1 | ALA4828709 | cell-based format | Scientific Literature |