| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4827633 | B | Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substrate addition measured by Amplex red and horseradish peroxidase based fluorescence assay | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 2. | ALA4827634 | B | Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyruvate and NADPH addition | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 3. | ALA4827635 | B | Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyruvate and NADPH addition | Mus musculus | 7 | assay format | Scientific Literature | ||
| 4. | ALA4827636 | B | Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after 30 mins by LC-MS analysis | Mus musculus | 6 | tissue-based format | Scientific Literature | ||
| 5. | ALA4827639 | F | In vivo inhibition of GOX/LDHA in C57BL/6N mouse assessed as increase in plasma glycolate levels at 100 mg/kg, po measured after 6 hrs | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 6. | ALA4827641 | A | Drug distribution in C57BL/6N mouse liver at 100 mg/kg, po measured after 6 hrs by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature |
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