# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4835035 | Functional | Antiproliferative activity against human NCI-H929 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay | Homo sapiens | 2 | ALA4834403 | cell-based format | Scientific Literature | |
2. | ALA4835036 | Functional | Antiproliferative activity against human KMS-28BM cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay | Homo sapiens | 2 | ALA4834403 | cell-based format | Scientific Literature | |
3. | ALA4835037 | Functional | Antiproliferative activity against human JJN-3 cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay | Homo sapiens | 2 | ALA4834403 | cell-based format | Scientific Literature | |
4. | ALA4835056 | Binding | Inhibition of full length human C-terminal His-tagged/C-terminal Flag-tagged HDAC1 using fluorogenic acetylated peptide as substrate incubated for 30 mins by fluorescence plate reader assay | Homo sapiens | 37 | ALA4834403 | single protein format | Scientific Literature | |
5. | ALA4835057 | Binding | Inhibition of full length human C-terminal His-tagged HDAC2 using fluorogenic acetylated peptide as substrate incubated for 30 mins by fluorescence plate reader assay | Homo sapiens | 31 | ALA4834403 | single protein format | Scientific Literature | |
6. | ALA4835058 | Binding | Inhibition of full length human C-terminal His-tagged HDAC3/human N-terminal GST-agged NCOR2 using fluorogenic acetylated peptide as substrate incubated for 30 mins by fluorescence plate reader assay | Homo sapiens | 31 | ALA4834403 | protein complex format | Scientific Literature | |
7. | ALA4835059 | Binding | Inhibition of full length human N-terminal GST-tagged HDAC6 using fluorogenic acetylated peptide as substrate incubated for 30 mins by fluorescence plate reader assay | Homo sapiens | 37 | ALA4834403 | single protein format | Scientific Literature | |
8. | ALA4835060 | Binding | Inhibition of human G9a enzyme using histone monomethyl-H3K9 peptide as substrate incubated for 1 hr in presence of SAM by TR-FRET assay | Homo sapiens | 37 | ALA4834403 | single protein format | Scientific Literature | |
9. | ALA4835061 | Binding | Inhibition of human DNMT1 enzyme using polydeoxy-inosine polydeoxy-cytosine DNA as substrate incubated for 15 mins in presence of SAM by TR-FRET assay | Homo sapiens | 37 | ALA4834403 | single protein format | Scientific Literature | |
10. | ALA4835062 | Functional | Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured up to 72 hrs by CellTiter96 Aqueous one reagent based assay | Homo sapiens | 23 | ALA4834403 | cell-based format | Scientific Literature | |
11. | ALA4835063 | ADME | Cytotoxicity against human THLE-2 cells assessed as decrease in cell viability measured after 72 hrs by Vialight-plus cell proliferation assay | Homo sapiens | 23 | ALA4834403 | cell-based format | Scientific Literature | |
12. | ALA4835064 | ADME | Permeability of the compound in PBS/EtOH buffer (70:30) incubated for 18 hrs by UV plate reader based PAMPA assay | 23 | ALA4834403 | assay format | Scientific Literature | ||
13. | ALA4835065 | Binding | Inhibition of HDAC in human MM1.S cells assessed as increase in H3K9Ac at > 500 nM after 48 hrs by Western blot analysis | Homo sapiens | 2 | ALA4834403 | cell-based format | Scientific Literature | |
14. | ALA4835068 | Binding | Inhibition of G9A in human MM1.S cells assessed as decrease in H3K9Me2 levels up to 1000 nM after 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA4834403 | cell-based format | Scientific Literature | |
15. | ALA4835071 | Binding | Induction of DNA hypomethylation in human MM1.S cells assessed as CPG hypomethylation at position 4 at 10 nM measured after 5 days relative to control | Homo sapiens | 1 | ALA4834403 | cell-based format | Scientific Literature | |
16. | ALA4835072 | Binding | Induction of DNA hypomethylation in human MM1.S cells assessed as CPG hypomethylation at position 5 at 10 nM measured after 5 days relative to control | Homo sapiens | 1 | ALA4834403 | cell-based format | Scientific Literature | |
17. | ALA4835075 | ADME | Inhibition of CYP1A2 in human liver microsomes at 10 uM incubated for 10 mins in presence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4834403 | microsome format | Scientific Literature | |
18. | ALA4835076 | ADME | Inhibition of CYP2C9 in human liver microsomes at 10 uM incubated for 10 mins in presence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4834403 | microsome format | Scientific Literature | |
19. | ALA4835077 | ADME | Inhibition of CYP2C19 in human liver microsomes at 10 uM incubated for 10 mins in presence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4834403 | microsome format | Scientific Literature | |
20. | ALA4835078 | ADME | Inhibition of CYP2D6 in human liver microsomes at 10 uM incubated for 10 mins in presence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4834403 | microsome format | Scientific Literature |