| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4823699 | Binding | Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as substrate incubated for 30 mins in presence of ATP by ELISA | Homo sapiens | 32 | ALA4823251 | single protein format | Scientific Literature | |
| 2. | ALA4823700 | Binding | Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity assay | Homo sapiens | 32 | ALA4823251 | cell-based format | Scientific Literature | |
| 3. | ALA4823701 | Binding | Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 mins in presence of ATP at Km concentration by luminescence assay | Homo sapiens | 29 | ALA4823251 | assay format | Scientific Literature | |
| 4. | ALA4823702 | Binding | Selectivity ratio of Ki for full length recombinant GST-tagged VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 mins in presence of ATP at Km concentration by luminescence assay to Ki for full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as substrate incubated for 30 mins in presence of ATP by ELISA | Homo sapiens | 27 | ALA4823251 | assay format | Scientific Literature | |
| 5. | ALA4823703 | Physicochemical | Kinetic solubility of the compound in pH 7.4 PBS buffer incubated for 2 hrs using orbital shaker by LC-UV mass spectrometry | 31 | ALA4823251 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA4823707 | Binding | Inhibition of DNA-PK isolated from human HeLa nuclear extract using full length His-tagged p53 as substrate measured after 75 mins in presence of ATP by HTRF assay | Homo sapiens | 4 | ALA4823251 | subcellular format | Scientific Literature | |
| 7. | ALA4823708 | Binding | Inhibition of ATR in human HT-29 cells assessed as reduction in CHK1 phosphorylation incubated for 4 hrs | Homo sapiens | 5 | ALA4823251 | cell-based format | Scientific Literature | |
| 8. | ALA4823710 | Binding | Selectivity ratio of Ki for DNA-PK isolated from human HeLa nuclear extract using full length His-tagged p53 as substrate measured after 75 mins in presence of ATP by HTRF assay to Ki for full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as substrate incubated for 30 mins in presence of ATP by ELISA | Homo sapiens | 4 | ALA4823251 | assay format | Scientific Literature |
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