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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4843234 Binding Inhibition of IDO1 in mouse Panc02 cells assessed as reduction in NFK level incubated for 48 hrs by RFMS analysis Mus musculus 7 ALA4842341 cell-based format Scientific Literature 2. ALA4843237 Binding Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assay Homo sapiens 62 ALA4842341 cell-based format Scientific Literature 3. ALA4843239 ADME Intrinsic clearance in human liver microsomes at 1 uM measured up to 45 mins in presence of NADPH by LC-MS/MS analysis Homo sapiens 48 ALA4842341 microsome format Scientific Literature 4. ALA4843244 ADME Clearance in CD-1 mouse at 0.3 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis Mus musculus 7 ALA4842341 organism-based format Scientific Literature 5. ALA4843245 ADME Volume of distribution at steady state in CD-1 mouse at 0.3 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis Mus musculus 7 ALA4842341 organism-based format Scientific Literature 6. ALA4843246 ADME Terminal half life in CD-1 mouse at 0.3 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis Mus musculus 7 ALA4842341 organism-based format Scientific Literature 7. ALA4843247 ADME AUC (0 to infinity) in CD-1 mouse at 0.3 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis Mus musculus 7 ALA4842341 organism-based format Scientific Literature 8. ALA4843248 ADME Cmax in CD-1 mouse at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis Mus musculus 7 ALA4842341 organism-based format Scientific Literature 9. ALA4843249 ADME Oral bioavailability in CD-1 mouse at 10 mg/kg measured upto 24 hrs by LC-MS/MS analysis Mus musculus 7 ALA4842341 organism-based format Scientific Literature 10. ALA4843250 Binding Inhibition of human ERG by fluorescence polarization assay Homo sapiens 6 ALA4842341 single protein format Scientific Literature 11. ALA4843253 Binding Inhibition of human ERG by manual patch clamp method Homo sapiens 4 ALA4842341 assay format Scientific Literature 12. ALA4843254 Binding Selectivity ratio of IC50 for inhibition of human ERG by manual patch clamp method to IC50 for inhibition of IDO1 in human HeLa cells Homo sapiens 10 ALA4842341 cell-based format Scientific Literature 13. ALA4843276 ADME Protein binding in human plasma at 5 uM incubated for 5 hrs by rapid equilibrium dialysis Homo sapiens 45 ALA4842341 cell-free format Scientific Literature 14. ALA4843280 ADME Inhibition of CYP2C9 in human liver microsomes using sulfaphenazole as substrate incubated for 10 mins in presence of NADPH by LCMS/MS analysis Homo sapiens 27 ALA4842341 microsome format Scientific Literature 15. ALA4843294 ADME Drug concentration in tumor of NSG mouse xenografted with human SKOV3 cells at 3 mg/kg, po QD measured at 24 hrs post dose Mus musculus 2 ALA4842341 organism-based format Scientific Literature 16. ALA4843295 ADME Drug concentration in tumor of NSG mouse xenografted with human SKOV3 cells at 50 mg/kg, po QD measured at 24 hrs post dose Mus musculus 1 ALA4842341 organism-based format Scientific Literature 17. ALA4843299 ADME Drug concentration in plasma of NSG mouse xenografted with human SKOV3 cells at 3 mg/kg, po QD measured at 24 hrs post dose Mus musculus 2 ALA4842341 organism-based format Scientific Literature 18. ALA4843300 ADME Drug concentration in plasma of NSG mouse xenografted with human SKOV3 cells at 50 mg/kg, po QD measured at 24 hrs post dose Mus musculus 1 ALA4842341 organism-based format Scientific Literature 19. ALA4843301 ADME Protein binding in mouse plasma at 5 uM incubated for 5 hrs by rapid equilibrium dialysis based LC-MS/MS analysis Mus musculus 13 ALA4842341 cell-free format Scientific Literature 20. ALA4843305 Functional In vivo inhibition of IDO1 in tumor of NSG mouse xenografted with human SKOV3 cells assessed as KYN level at 3 mg/kg, po QD measured at 24 hrs post dose Mus musculus 2 ALA4842341 organism-based format Scientific Literature