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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4843234 B Inhibition of IDO1 in mouse Panc02 cells assessed as reduction in NFK level incubated for 48 hrs by RFMS analysis Mus musculus 7 cell-based format Scientific Literature 2. ALA4843237 B Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assay Homo sapiens 62 cell-based format Scientific Literature 3. ALA4843239 A Intrinsic clearance in human liver microsomes at 1 uM measured up to 45 mins in presence of NADPH by LC-MS/MS analysis Homo sapiens 48 microsome format Scientific Literature 4. ALA4843244 A Clearance in CD-1 mouse at 0.3 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis Mus musculus 7 organism-based format Scientific Literature 5. ALA4843245 A Volume of distribution at steady state in CD-1 mouse at 0.3 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis Mus musculus 7 organism-based format Scientific Literature 6. ALA4843246 A Terminal half life in CD-1 mouse at 0.3 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis Mus musculus 7 organism-based format Scientific Literature 7. ALA4843247 A AUC (0 to infinity) in CD-1 mouse at 0.3 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis Mus musculus 7 organism-based format Scientific Literature 8. ALA4843248 A Cmax in CD-1 mouse at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis Mus musculus 7 organism-based format Scientific Literature 9. ALA4843249 A Oral bioavailability in CD-1 mouse at 10 mg/kg measured upto 24 hrs by LC-MS/MS analysis Mus musculus 7 organism-based format Scientific Literature 10. ALA4843250 B Inhibition of human ERG by fluorescence polarization assay Homo sapiens 6 single protein format Scientific Literature 11. ALA4843253 B Inhibition of human ERG by manual patch clamp method Homo sapiens 4 assay format Scientific Literature 12. ALA4843254 B Selectivity ratio of IC50 for inhibition of human ERG by manual patch clamp method to IC50 for inhibition of IDO1 in human HeLa cells Homo sapiens 10 cell-based format Scientific Literature 13. ALA4843276 A Protein binding in human plasma at 5 uM incubated for 5 hrs by rapid equilibrium dialysis Homo sapiens 45 cell-free format Scientific Literature 14. ALA4843280 A Inhibition of CYP2C9 in human liver microsomes using sulfaphenazole as substrate incubated for 10 mins in presence of NADPH by LCMS/MS analysis Homo sapiens 27 microsome format Scientific Literature 15. ALA4843294 A Drug concentration in tumor of NSG mouse xenografted with human SKOV3 cells at 3 mg/kg, po QD measured at 24 hrs post dose Mus musculus 2 organism-based format Scientific Literature 16. ALA4843295 A Drug concentration in tumor of NSG mouse xenografted with human SKOV3 cells at 50 mg/kg, po QD measured at 24 hrs post dose Mus musculus 1 organism-based format Scientific Literature 17. ALA4843299 A Drug concentration in plasma of NSG mouse xenografted with human SKOV3 cells at 3 mg/kg, po QD measured at 24 hrs post dose Mus musculus 2 organism-based format Scientific Literature 18. ALA4843300 A Drug concentration in plasma of NSG mouse xenografted with human SKOV3 cells at 50 mg/kg, po QD measured at 24 hrs post dose Mus musculus 1 organism-based format Scientific Literature 19. ALA4843301 A Protein binding in mouse plasma at 5 uM incubated for 5 hrs by rapid equilibrium dialysis based LC-MS/MS analysis Mus musculus 13 cell-free format Scientific Literature 20. ALA4843305 F In vivo inhibition of IDO1 in tumor of NSG mouse xenografted with human SKOV3 cells assessed as KYN level at 3 mg/kg, po QD measured at 24 hrs post dose Mus musculus 2 organism-based format Scientific Literature