# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4831679 | F | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as bacterial growth inhibition incubated for 7 days by microplate Alamar blue assay | Mycobacterium tuberculosis | 46 | organism-based format | Scientific Literature | ||
2. | ALA4831680 | A | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | Chlorocebus sabaeus | 29 | cell-based format | Scientific Literature | ||
3. | ALA4831681 | T | Selectivity index, ratio of IC50 for African green monkey Vero cells to MIC for antitubercular activity against Mycobacterium tuberculosis H37Rv | 29 | assay format | Scientific Literature | |||
4. | ALA4831682 | B | Non-covalent inhibition of DprE1 in Mycobacterium tuberculosis H37Rv measured after 7 days by microplate Alamar blue assay | Mycobacterium tuberculosis H37Rv | 12 | single protein format | Scientific Literature | ||
5. | ALA4831683 | B | Non-covalent inhibition of DprE1 in multidrug-resistant Mycobacterium tuberculosis clinical isolate 13946 measured after 7 days by microplate Alamar blue assay | Mycobacterium tuberculosis | 10 | assay format | Scientific Literature | ||
6. | ALA4831684 | B | Non-covalent inhibition of DprE1 in multidrug-resistant Mycobacterium tuberculosis clinical isolate 14862 measured after 7 days by microplate Alamar blue assay | Mycobacterium tuberculosis | 10 | assay format | Scientific Literature | ||
7. | ALA4831687 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in mouse J774.1 cells assessed as reduction in bacterial colony forming units at 10 ug/ml incubated for 3 days (Rvb = 5.52 +/- 0.18 log10CFU) | Mycobacterium tuberculosis | 6 | organism-based format | Scientific Literature | ||
8. | ALA4831688 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in mouse J774.1 cells assessed as change in bacterial colony forming units at 10 ug/ml incubated for 3 days | Mycobacterium tuberculosis | 6 | organism-based format | Scientific Literature | ||
9. | ALA4831689 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in mouse J774.1 cells assessed as reduction in bacterial colony forming units at 5 ug/ml incubated for 3 days (Rvb = 5.52 +/- 0.18 log10CFU) | Mycobacterium tuberculosis | 7 | organism-based format | Scientific Literature | ||
10. | ALA4831690 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in mouse J774.1 cells assessed as change in bacterial colony forming units at 5 ug/ml incubated for 3 days | Mycobacterium tuberculosis | 7 | organism-based format | Scientific Literature | ||
11. | ALA4831714 | F | Antibacterial activity against Mycobacterium bovis BCG transfected with pMV261:Mt-dprE1 assessed as bacterial growth inhibition incubated for 7 days by resazurin assay | Mycobacterium tuberculosis | 7 | organism-based format | Scientific Literature | ||
12. | ALA4831715 | F | Antibacterial activity against Mycobacterium bovis BCG transfected with pMV261:Mt-dprE2 assessed as bacterial growth inhibition incubated for 7 days by resazurin assay | Mycobacterium tuberculosis | 7 | organism-based format | Scientific Literature | ||
13. | ALA4831716 | F | Antibacterial activity against wild type Mycobacterium bovis BCG assessed as bacterial growth inhibition incubated for 7 days by resazurin assay | Mycobacterium tuberculosis | 7 | organism-based format | Scientific Literature | ||
14. | ALA4831717 | F | Ratio of MIC for Mycobacterium bovis BCG transfected with pMV261:Mt-dprE1 to MIC for wild type Mycobacterium bovis BCG | 7 | assay format | Scientific Literature | |||
15. | ALA4831718 | B | Inhibition of Mycobacterium tuberculosis H37Rv DprE1 using FAD as substrate by resazurin based assay | Mycobacterium tuberculosis H37Rv | 7 | single protein format | Scientific Literature |