# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4826128 | Functional | Antiproliferative activity against human PC-9 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Homo sapiens | 8 | ALA4825665 | cell-based format | Scientific Literature | |
2. | ALA4826129 | Functional | Antiproliferative activity against human PB1 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Homo sapiens | 8 | ALA4825665 | cell-based format | Scientific Literature | |
3. | ALA4826130 | Functional | Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Homo sapiens | 8 | ALA4825665 | cell-based format | Scientific Literature | |
4. | ALA4826131 | Functional | Antiproliferative activity against human HCC827 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Homo sapiens | 8 | ALA4825665 | cell-based format | Scientific Literature | |
5. | ALA4826132 | Functional | Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Homo sapiens | 8 | ALA4825665 | cell-based format | Scientific Literature | |
6. | ALA4826133 | Functional | Antiproliferative activity against mouse BaF3 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Mus musculus | 8 | ALA4825665 | cell-based format | Scientific Literature | |
7. | ALA4826134 | ADME | Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Homo sapiens | 8 | ALA4825665 | cell-based format | Scientific Literature | |
8. | ALA4826135 | ADME | Cytotoxicity against human BJ cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay | Homo sapiens | 8 | ALA4825665 | cell-based format | Scientific Literature | |
9. | ALA4826136 | Binding | Protac activity at CRBN/EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as induction of EGFR degradation measured after 16 hrs by Western blot assay | Homo sapiens | 2 | ALA4825665 | cell-based format | Scientific Literature | |
10. | ALA4826137 | Binding | Protac activity at CRBN/EGFR in human PC-9 cells assessed as induction of EGFR degradation by Western blot assay | Homo sapiens | 8 | ALA4825665 | cell-based format | Scientific Literature | |
11. | ALA4826138 | Binding | Protac activity at CRBN/EGFR in human PB1 cells assessed as induction of EGFR degradation by Western blot assay | Homo sapiens | 8 | ALA4825665 | cell-based format | Scientific Literature | |
12. | ALA4826139 | Binding | Protac activity at CRBN/EGFR in human NCI-H1975 cells assessed as induction of EGFR degradation by Western blot assay | Homo sapiens | 8 | ALA4825665 | cell-based format | Scientific Literature | |
13. | ALA4826140 | Binding | Protac activity at CRBN/EGFR in human A549 cells assessed as induction of EGFR degradation by Western blot assay | Homo sapiens | 8 | ALA4825665 | cell-based format | Scientific Literature | |
14. | ALA4826141 | Binding | Protac activity at CRBN/EGFR in mouse BaF3 cells assessed as induction of EGFR degradation by Western blot assay | Mus musculus | 8 | ALA4825665 | cell-based format | Scientific Literature | |
15. | ALA4826142 | Binding | Protac activity at CRBN/EGFR exon 19 deletion mutant in human PC-9 cells assessed as induction of EGFR degradation at >10 nM measured after 48 hrs by Western blot assay | Homo sapiens | 2 | ALA4825665 | cell-based format | Scientific Literature | |
16. | ALA4826144 | Binding | Protac activity at CRBN/EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as induction of EGFR degradation at 30 nM measured after 16 hrs by Western blot assay | Homo sapiens | 1 | ALA4825665 | cell-based format | Scientific Literature | |
17. | ALA4826145 | Binding | Protac activity at CRBN/EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as induction of EGFR degradation measured after 48 hrs by Western blot assay | Homo sapiens | 2 | ALA4825665 | cell-based format | Scientific Literature | |
18. | ALA4826146 | Binding | Protac activity at CRBN/EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as induction of EGFR degradation at 300 nM measured after 8 to 72 hrs by Western blot assay relative to control | Homo sapiens | 2 | ALA4825665 | cell-based format | Scientific Literature | |
19. | ALA4826147 | Binding | Protac activity at CRBN/EGFR exon19 deletion/T790M mutant in human PC-9 cells transfected with BRCA1 assessed as induction of EGFR degradation at 1 to 1000 nM measured after 16 hrs by Western blot assay | Homo sapiens | 2 | ALA4825665 | cell-based format | Scientific Literature | |
20. | ALA4826148 | Binding | Protac activity at CRBN/EGFR exon19 deletion/T790M mutant in human PC-9 cells transfected with BRCA1 assessed as induction of EGFR degradation at 1 to 1000 nM measured after 48 hrs by Western blot assay | Homo sapiens | 2 | ALA4825665 | cell-based format | Scientific Literature |