| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4834365 | A | Inhibition of human CYP3A4 using testosterone as a substrate by LC/MS/MS analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 2. | ALA4834366 | B | Inhibition of Plasmodium falciparum PKG using FAM-labeled PKAtide or IP3R-derived peptide as a substrate preincubated for 15 mins followed by substrate addition and incubated for 60 mins by IMAP assay | Plasmodium falciparum | 8 | assay format | Scientific Literature | ||
| 3. | ALA4834368 | B | Inhibition of human PKG using FAM-labeled PKAtide or IP3R-derived peptide as a substrate at 10 uM preincubated for 15 mins followed by substrate addition and incubated for 60 mins by IMAP assay relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA4834369 | B | Inhibition of Plasmodium falciparum PKG T618Q mutant using FAM-labeled PKAtide or IP3R-derived peptide as a substrate at 10 uM preincubated for 15 mins followed by substrate addition and incubated for 60 mins by IMAP assay relative to control | Plasmodium falciparum | 1 | single protein format | Scientific Literature | ||
| 5. | ALA4834370 | A | Metabolic stability in human liver microsomes assessed as half life incubated for 60 mins in the presence of NADPH by LC-MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 6. | ALA4834371 | A | Metabolic stability in mouse liver microsomes assessed as half life incubated for 60 mins in the presence of NADPH by LC-MS/MS analysis | Mus musculus | 3 | microsome format | Scientific Literature | ||
| 7. | ALA4834372 | P | Kinetic aqueous solubility of the compound at pH 7.4 measured after 1 hr by UV/LC-MS/MS analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA4834376 | F | Antiplasmodial activity against luciferase expressing Plasmodium berghei sporozoites infected in HepG2 cells assessed as decrease in parasite infection at 2 uM incubated for 16 hrs followed by replacement with compound free medium and measured after 48 hrs post infection by IVIS spectrum in vivo imaging analysis relative to control | Plasmodium berghei | 5 | organism-based format | Scientific Literature | ||
| 9. | ALA4834377 | F | Antiplasmodial activity against luciferase expressing Plasmodium berghei sporozoites infected in HepG2 cells assessed as decrease in parasite infection at 10 uM incubated for 16 hrs followed by replacement with compound free medium measured after 48 hrs post infection by IVIS spectrum in vivo imaging analysis relative to control | Plasmodium berghei | 5 | organism-based format | Scientific Literature | ||
| 10. | ALA4834380 | F | Antiplasmodial activity against liver stage Plasmodium cynomolgi B infected in non-human primate hepatocytes assessed as inhibition of liver schizonts development incubated for 4 days from sporozoite addition by prophylactic assay | Plasmodium cynomolgi | 4 | organism-based format | Scientific Literature | ||
| 11. | ALA4834381 | F | Antiplasmodial activity against liver stage Plasmodium cynomolgi B infected in non-human primate hepatocytes assessed as inhibition of hypnozoite development incubated for 4 days from sporozoite addition by prophylactic assay | Plasmodium cynomolgi | 4 | organism-based format | Scientific Literature | ||
| 12. | ALA4834382 | F | Antiplasmodial activity against liver stage Plasmodium cynomolgi B infected in non-human primate hepatocytes assessed as reduction in liver schizonts development incubated for 4 days starting on day 4 post-sporozoite inoculation by radial cure mode analysis | Plasmodium cynomolgi | 4 | organism-based format | Scientific Literature | ||
| 13. | ALA4834383 | F | Antiplasmodial activity against liver stage Plasmodium cynomolgi B infected in non-human primate hepatocytes assessed as reduction in liver hypnozoites development incubated for 4 days starting on day 4 post-sporozoite inoculation by radial cure mode analysis | Plasmodium cynomolgi | 4 | organism-based format | Scientific Literature | ||
| 14. | ALA4834384 | A | Toxicity against non-human primate hepatocytes infected with liver stage Plasmodium cynomolgi B incubated for 4 days from sporozoite addition | Primates | 4 | tissue-based format | Scientific Literature | ||
| 15. | ALA4834385 | A | Toxicity against non-human primate hepatocytes infected with liver stage Plasmodium cynomolgi B incubated for 4 days starting on day 4 post-sporozoite inoculation | Primates | 4 | tissue-based format | Scientific Literature |
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