# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4808885 | Binding | Displacement of 125I-glucagon from human GCGR expressed in HEK293 cells membranes incubated for 6 hrs by liquid scintillation counting method | Homo sapiens | 27 | ALA4808176 | cell membrane format | Scientific Literature | |
2. | ALA4808886 | Functional | Antagonist activity at human GCGR expressed in HEK293 cells assessed as inhibition of glucogon-induced cAMP production | Homo sapiens | 19 | ALA4808176 | cell-based format | Scientific Literature | |
3. | ALA4808892 | Functional | Antagonist activity at human GCGR expressed in HEK293 cells assessed as inhibition of glucogon-induced cAMP production relative to control | Homo sapiens | 2 | ALA4808176 | cell-based format | Scientific Literature | |
4. | ALA4808893 | Functional | Antagonist activity at human GIPR expressed in HEK293 cells assessed as inhibition of GIP-induced cAMP production | Homo sapiens | 2 | ALA4808176 | cell-based format | Scientific Literature | |
5. | ALA4808894 | Functional | Antagonist activity at human GIPR expressed in HEK293 cells assessed as inhibition of GIP-induced cAMP production relative to control | Homo sapiens | 2 | ALA4808176 | cell-based format | Scientific Literature | |
6. | ALA4808895 | Functional | Antagonist activity at human GLP-1R expressed in HEK293 cells assessed as inhibition of GLP1-induced cAMP production | Homo sapiens | 2 | ALA4808176 | cell-based format | Scientific Literature | |
7. | ALA4808896 | Functional | Antagonist activity at human GLP-1R expressed in HEK293 cells assessed as inhibition of GLP1-induced cAMP production relative to control | Homo sapiens | 2 | ALA4808176 | cell-based format | Scientific Literature | |
8. | ALA4808897 | Functional | Antagonist activity at mouse GCGR expressed in CHO-K1 cells assessed as inhibition of glucogon-induced cAMP production relative to control | Mus musculus | 2 | ALA4808176 | cell-based format | Scientific Literature | |
9. | ALA4808898 | Functional | Antagonist activity at mouse GCGR expressed in CHO-K1 cells assessed as inhibition of glucogon-induced cAMP production | Mus musculus | 2 | ALA4808176 | cell-based format | Scientific Literature | |
10. | ALA4808899 | Binding | Antagonist activity at mouse GIPR expressed in CHO-K1 cells assessed as inhibition of GIP-induced cAMP production | Mus musculus | 2 | ALA4808176 | cell-based format | Scientific Literature | |
11. | ALA4808900 | Binding | Antagonist activity at mouse GIPR expressed in CHO-K1 cells assessed as inhibition of GIP-induced cAMP production relative to control | Mus musculus | 2 | ALA4808176 | cell-based format | Scientific Literature | |
12. | ALA4808901 | Functional | Antagonist activity at mouse GLP1R expressed in CHO-K1 cells assessed as inhibition of GLP1-induced cAMP production | Mus musculus | 2 | ALA4808176 | cell-based format | Scientific Literature | |
13. | ALA4808902 | Functional | Antagonist activity at mouse GLP1R expressed in CHO-K1 cells assessed as inhibition of GLP1-induced cAMP production relative to control | Mus musculus | 2 | ALA4808176 | cell-based format | Scientific Literature | |
14. | ALA4808904 | Functional | Inhibition of IUB288-induced glucose elevation in C57BL/6 mouse at 1500 nmol/kg, sc pretreated for 4 to 8 hrs followed by IUB288 stimulation and measured upto 4 hrs | Mus musculus | 1 | ALA4808176 | organism-based format | Scientific Literature | |
15. | ALA4808905 | Functional | Inhibition of IUB288-induced glucose elevation in C57BL/6 mouse at 1500 nmol/kg, sc pretreated for 24 hrs followed by IUB288 stimulation and measured upto 4 hrs | Mus musculus | 1 | ALA4808176 | organism-based format | Scientific Literature | |
16. | ALA4808906 | Toxicity | Toxicity in C57BL/6 mouse assessed as adverse local and systemic responses at 1500 nmol/kg, sc | Mus musculus | 2 | ALA4808176 | assay format | Scientific Literature | |
17. | ALA4808908 | ADME | Half life in C57BL/6 mouse at 1500 nmol/kg, sc measured upto 48 hrs by LC-MS analysis | Mus musculus | 1 | ALA4808176 | organism-based format | Scientific Literature | |
18. | ALA4808910 | ADME | Cmax in C57BL/6 mouse at 1500 nmol/kg, sc measured upto 48 hrs by LC-MS analysis | Mus musculus | 1 | ALA4808176 | organism-based format | Scientific Literature | |
19. | ALA4808912 | ADME | AUC in C57BL/6 mouse at 1500 nmol/kg, sc measured upto 48 hrs by LC-MS analysis | Mus musculus | 1 | ALA4808176 | organism-based format | Scientific Literature | |
20. | ALA4808914 | Physicochemical | Chemical stability of compound in PBS buffer incubated for 5 to 7 days by LC-MS analysis | 2 | ALA4808176 | small-molecule physicochemical format | Scientific Literature |