# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4820957 | B | Antagonist activity at human AM2 expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition in presence of IBMX and measured after 15 mins by TR-FRET assay | Homo sapiens | 28 | ALA4819041 | cell-based format | Scientific Literature | |
2. | ALA4820958 | A | Antagonist activity at human AM1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition in presence of IBMX and measured after 15 mins by TR-FRET assay | Homo sapiens | 24 | ALA4819041 | cell-based format | Scientific Literature | |
3. | ALA4820959 | B | Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 30 mins followed by forskolin addition in presence of IBMX and measured after 15 mins by TR-FRET assay | Homo sapiens | 24 | ALA4819041 | cell-based format | Scientific Literature | |
4. | ALA4820960 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability at 10 uM incubated for 3 days by real-time-Glo Luminescent cell viability assay relative to control | Homo sapiens | 1 | ALA4819041 | cell-based format | Scientific Literature | |
5. | ALA4820961 | F | Antitumor activity against human MDA-MB-231 cells xenografted in Balb/c nude mouse assessed as tumor growth inhibition at 20 mg/kg, ip QD and measured after 4 weeks post treatment | Homo sapiens | 1 | ALA4819041 | organism-based format | Scientific Literature | |
6. | ALA4820962 | T | Toxicity in Balb/c nude mouse xenografted with human MDA-MB-231 cells assessed as dose toleration at 20 mg/kg, ip QD | Mus musculus | 1 | ALA4819041 | organism-based format | Scientific Literature | |
7. | ALA4820963 | T | Toxicity in Balb/c nude mouse xenografted with human MDA-MB-231 cells assessed as change in body weight at 20 mg/kg, ip QD | Mus musculus | 1 | ALA4819041 | organism-based format | Scientific Literature | |
8. | ALA4820964 | T | Toxicity in Balb/c nude mouse xenografted with human MDA-MB-231 cells assessed as adverse effect at 20 mg/kg, ip QD | Mus musculus | 1 | ALA4819041 | organism-based format | Scientific Literature | |
9. | ALA4820965 | T | Toxicity in Balb/c nude mouse xenografted with human MDA-MB-231 cells assessed as normal feeding at 20 mg/kg, ip QD | Mus musculus | 1 | ALA4819041 | organism-based format | Scientific Literature | |
10. | ALA4820966 | T | Toxicity in Balb/c nude mouse xenografted with human MDA-MB-231 cells assessed as normal inquisitiveness at 20 mg/kg, ip QD | Mus musculus | 1 | ALA4819041 | organism-based format | Scientific Literature |