# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4844304 | Binding | Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assay | Homo sapiens | 31 | ALA4842364 | single protein format | Scientific Literature | |
2. | ALA4844305 | Functional | Antiproliferative activity against human NCI-H23 cells assessed as reduction in cell viability after 4 days by CellTiter-Glo assay | Homo sapiens | 31 | ALA4842364 | cell-based format | Scientific Literature | |
3. | ALA4844306 | Physicochemical | Octanol/buffer distribution coefficient, logD of the compound at pH 7.4 | 28 | ALA4842364 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4844308 | ADME | Intrinsic clearance in human microsomes | Homo sapiens | 22 | ALA4842364 | microsome format | Scientific Literature | |
5. | ALA4844313 | ADME | Intrinsic clearance in mouse microsomes | Mus musculus | 26 | ALA4842364 | microsome format | Scientific Literature | |
6. | ALA4844315 | ADME | AUC(0 to 24 hrs) in mouse at 60 mg/kg, po | Mus musculus | 17 | ALA4842364 | organism-based format | Scientific Literature | |
7. | ALA4844316 | ADME | AUC(0 to 24 hrs) in rat at 60 mg/kg, po | Rattus norvegicus | 10 | ALA4842364 | organism-based format | Scientific Literature | |
8. | ALA4844351 | Functional | Antitumor activity against human A-427 cells xenografted in SCID mouse assessed as reduction in tumor growth at 80 mg/kg, po administered once daily for 28 days and measured twice per weeks | Homo sapiens | 3 | ALA4842364 | organism-based format | Scientific Literature | |
9. | ALA4844352 | ADME | AUC in mouse plasma at 80 mg/kg, po administered once daily for 28 days | Mus musculus | 3 | ALA4842364 | organism-based format | Scientific Literature | |
10. | ALA4844353 | Functional | Antiproliferative activity against human A-427 cells assessed as reduction in cell viability after 3 days by CellTiter-Glo assay | Homo sapiens | 3 | ALA4842364 | cell-based format | Scientific Literature |