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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4845505 F Antagonist activity at CXCR4 receptor in human CCRF-CEM cells assessed as inhibition of SDF-1alpha-induced calcium release preincubated for 25 mins followed by SDF-1alpha addition and monitered for 90 sec Homo sapiens 15 cell-based format Scientific Literature 2. ALA4845506 B Antagonist activity at muscarinic acetylcholine receptor in human CCRF-CEM cells assessed as inhibition of acetylcholine-induced calcium release preincubated for 25 mins followed by acetylcholine addition and monitered for 90 sec Homo sapiens 15 cell-based format Scientific Literature 3. ALA4845507 A Metabolic stability in human liver microsomes assessed as parent compound remaining incubated for 10 mins in presence of NADPH Homo sapiens 15 microsome format Scientific Literature 4. ALA4845508 A Metabolic stability in rat liver microsomes assessed as parent compound remaining incubated for 10 mins in presence of NADPH Rattus norvegicus 15 microsome format Scientific Literature 5. ALA4845509 A Metabolic stability in mouse liver microsomes assessed as parent compound remaining incubated for 10 mins in presence of NADPH Mus musculus 15 microsome format Scientific Literature 6. ALA4845510 A Inhibition of human recombinant CYP2D6 expressed in insect cells using AMMC as substrate preincubated for 30 mins followed by NADPH regenerating system addition and measured after 45 mins by fluorescence based assay Homo sapiens 15 cell-based format Scientific Literature 7. ALA4845511 A Permeability of the compound at pH 7.4 incubated for 4 hrs by PAMPA 9 assay format Scientific Literature 8. ALA4845512 A Inhibition of CYP3A4 (unknown origin) Homo sapiens 15 single protein format Scientific Literature 9. ALA4845514 A Cmax in CD-1 mouse at 30 mg/kg, po or at 3 mg/kg, iv by UPLC-MS/MS analysis Mus musculus 2 organism-based format Scientific Literature 10. ALA4845515 A Cmax in CD-1 mouse at 30 mg/kg, po or at 3 mg/kg, iv measured up to 8 hrs by UPLC-MS/MS analysis Mus musculus 2 organism-based format Scientific Literature 11. ALA4845516 A Clearance in CD-1 mouse at 30 mg/kg, po or at 3 mg/kg, iv by UPLC-MS/MS analysis Mus musculus 2 organism-based format Scientific Literature 12. ALA4845517 A Volume of distribution in CD-1 mouse at 30 mg/kg, po or at 3 mg/kg, iv by UPLC-MS/MS analysis Mus musculus 2 organism-based format Scientific Literature 13. ALA4845520 A AUC (0 to t) in CD-1 mouse at 30 mg/kg, po or at 3 mg/kg, iv measured after 8 hrs by LC-MS/MS analysis Mus musculus 1 organism-based format Scientific Literature 14. ALA4845521 A Half life in CD1 mouse at 30 mg/kg, po or at 3 mg/kg, iv measured after 8 hrs by LC-MS/MS analysis Mus musculus 1 organism-based format Scientific Literature 15. ALA4845522 A Oral bioavailability in CD1 mouse at 30 mg/kg measured after 8 hrs by LC-MS/MS analysis Mus musculus 1 organism-based format Scientific Literature 16. ALA4845523 F Antagonist activity at CXCR1 (unknown origin) assessed as inhibition of ligand-induced calcium flux measured upto 10 uM Homo sapiens 1 assay format Scientific Literature 17. ALA4845524 F Antagonist activity at CXCR2 (unknown origin) assessed as inhibition of ligand-induced calcium flux measured upto 10 uM Homo sapiens 1 assay format Scientific Literature 18. ALA4845525 F Antagonist activity at CXCR3 (unknown origin) assessed as inhibition of ligand-induced calcium flux measured upto 10 uM Homo sapiens 1 assay format Scientific Literature 19. ALA4845526 F Antagonist activity at CCR4 (unknown origin) assessed as inhibition of ligand-induced calcium flux measured upto 10 uM Homo sapiens 1 assay format Scientific Literature 20. ALA4845527 F Antagonist activity at CCR5 (unknown origin) assessed as inhibition of ligand-induced calcium flux measured upto 10 uM Homo sapiens 1 assay format Scientific Literature