# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4825443 | B | Modulator activity at NF-kappaB in C57BL/6 mouse BMDC cells assessed as increase in cell surface CD40 expression at 200 nM measured after 8 hrs by FACS analysis | Mus musculus | 7 | cell-based format | Scientific Literature | ||
2. | ALA4825444 | B | Agonist activity at TLR7/8 in mouse RAW-blue cells assessed as immune activation by measuring induction of NFkappaB activation at 500 nM measured after 24 hrs by quanti-blue SEAP reporter gene-based assay | Mus musculus | 7 | cell-based format | Scientific Literature | ||
3. | ALA4825445 | A | Toxicity in C57BL/6 mouse BMDC cells assessed as induction of inflammation by measuring increase in IL-6 secretion at 200 nM measured after 8 hrs by ELISA | Mus musculus | 7 | cell-based format | Scientific Literature | ||
4. | ALA4825446 | F | Antioxidant activity in mouse RAW264.7 cells assessed as reduction in intracellular ROS level measured after 16 hrs by CM-H2DCFDA based flow cytometry analysis relative to TLR7/8 SMIP | Mus musculus | 6 | cell-based format | Scientific Literature | ||
5. | ALA4825447 | F | Inhibition of NO production in mouse RAW264.7 cells at 500 nM incubated for 16 hrs by Griess reagent based analysis | Mus musculus | 6 | cell-based format | Scientific Literature | ||
6. | ALA4825448 | F | Inhibition of COX-2 expression in mouse RAW264.7 cells at 500 nM incubated for 16 hrs by western blot analysis | Mus musculus | 6 | cell-based format | Scientific Literature | ||
7. | ALA4825449 | F | Inhibition of iNOS expression in mouse RAW264.7 cells at 500 nM incubated for 16 hrs by western blot analysis | Mus musculus | 6 | cell-based format | Scientific Literature | ||
8. | ALA4825450 | T | Systemic toxicity in C57BL/6 mouse assessed as increase in serum TNF-alpha level administered intramuscularly in presence of ovalbumin measured after 1 hr | Mus musculus | 3 | assay format | Scientific Literature | ||
9. | ALA4825451 | F | Immuno-adjuvant activity in C57BL/6 mouse assessed as increase in levels of anti-OVA Ig (A+G+M) administered intramuscularly on day 1 and as booster dose on day 14 in presence of ovalbumin and measured on day 28 by ELISA | Mus musculus | 2 | organism-based format | Scientific Literature | ||
10. | ALA4825452 | F | Induction of T-cell immunity in C57BL/6 mouse splenocytes assessed as increase in CD3+CD8+ tetramer administered intramuscularly on day 1 and as booster dose on day 14 in presence of ovalbumin and SINFEKL MHC specific tetramer measured on day 28 by flow cytometric analysis | Mus musculus | 3 | cell-based format | Scientific Literature | ||
11. | ALA4825453 | F | Induction of innate immunity in C57BL/6 mouse naive splenocyte assessed as increase in cell proliferation at 3 uM measured after 48 hrs by MTT assay | Mus musculus | 7 | tissue-based format | Scientific Literature | ||
12. | ALA4825454 | T | Systemic toxicity in CT26 cells xenografted BALB/c mouse tumor model assessed as increase in serum TNF-alpha level at 20 nmol, IT and measured after 2 hrs | Mus musculus | 8 | cell-based format | Scientific Literature | ||
13. | ALA4825455 | T | Systemic toxicity in CT26 cells xenografted BALB/c mouse tumor model assessed as increase in serum IL-6 level at 20 nmol, IT and measured after 2 hrs | Mus musculus | 9 | cell-based format | Scientific Literature | ||
14. | ALA4825456 | T | Systemic toxicity in CT26 cells xenografted BALB/c mouse tumor model assessed as reduction in white blood count in peripheral blood at 20 nmol, IT and measured after 24 hrs by hematological analysis | Mus musculus | 8 | cell-based format | Scientific Literature | ||
15. | ALA4825458 | T | Systemic toxicity in C57BL/6 mouse assessed as increase in serum IL-6 level administered intramuscularly in presence of ovalbumin measured after 1 hr | Mus musculus | 3 | assay format | Scientific Literature | ||
16. | ALA4825459 | F | Immuno-adjuvant activity in C57BL/6 mouse assessed as increase in levels of anti-OVA IgG administered intramuscularly on day 1 and as booster dose on day 14 in presence of ovalbumin and measured on day 28 by ELISA | Mus musculus | 2 | organism-based format | Scientific Literature | ||
17. | ALA4825461 | T | Systemic toxicity in CT26 cells xenografted BALB/c mouse tumor model assessed as reduction in lymphocyte count in peripheral blood at 20 nmol, IT and measured after 24 hrs by hematological analysis | Mus musculus | 9 | cell-based format | Scientific Literature |