| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4820467 | B | Agonist activity at VP16-AR wild-type (unknown origin) transfected in human HepG2 cells cotransfected with ARE-LUC at upto 30 uM incubated for 48 hrs by steady-glo luciferase reporter gene assay relative to control | Homo sapiens | 9 | ALA4819022 | cell-based format | Scientific Literature | |
| 2. | ALA4820468 | B | Antagonist activity at VP16-AR wild-type (unknown origin) transfected in human HepG2 cells cotransfected with ARE-LUC at upto 30 uM incubated for 48 hrs in presence of AR agonist R1881 by steady-glo luciferase reporter gene assay relative to control | Homo sapiens | 9 | ALA4819022 | cell-based format | Scientific Literature | |
| 3. | ALA4820469 | B | Agonist activity at VP16-AR F877L mutant (unknown origin) transfected in human HepG2 cells cotransfected with ARE-LUC incubated for 48 hrs by steady-glo luciferase reporter gene assay | Homo sapiens | 9 | ALA4819022 | cell-based format | Scientific Literature | |
| 4. | ALA4820470 | B | Agonist activity at VP16-AR F877L mutant (unknown origin) transfected in human HepG2 cells cotransfected with ARE-LUC at upto 30 uM incubated for 48 hrs by steady-glo luciferase reporter gene assay relative to control | Homo sapiens | 9 | ALA4819022 | cell-based format | Scientific Literature | |
| 5. | ALA4820471 | B | Antagonist activity at VP16-AR F877L mutant (unknown origin) transfected in human HepG2 cells cotransfected with ARE-LUC at upto 30 uM incubated for 48 hrs in presence of AR agonist R1881 by steady-glo luciferase reporter gene assay relative to control | Homo sapiens | 9 | ALA4819022 | cell-based format | Scientific Literature | |
| 6. | ALA4820474 | B | Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presence of AR agonist R1881 by steady-glo luciferase reporter gene assay | Homo sapiens | 15 | ALA4819022 | cell-based format | Scientific Literature | |
| 7. | ALA4820475 | B | Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presence of AR agonist R1881 by steady-glo luciferase reporter gene assay | Homo sapiens | 15 | ALA4819022 | cell-based format | Scientific Literature | |
| 8. | ALA4820477 | B | Antagonist activity at AR F877L mutant (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presence of AR agonist R1881 by steady-glo luciferase reporter gene assay relative to control | Homo sapiens | 14 | ALA4819022 | cell-based format | Scientific Literature | |
| 9. | ALA4820478 | B | Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presence of AR agonist R1881 by steady-glo luciferase reporter gene assay relative to control | Homo sapiens | 15 | ALA4819022 | cell-based format | Scientific Literature | |
| 10. | ALA4820479 | F | Antiproliferative activity against human VCaP cells expressing wild-type androgen receptor assessed as reduction in cell viability incubated for 5 days in presence of R1881 by CellTiter-glo assay | Homo sapiens | 11 | ALA4819022 | cell-based format | Scientific Literature | |
| 11. | ALA4820486 | F | Antitumor activity against human LNCaP cells harboring AR F877L mutant xenografted in SCID mouse assessed as tumor growth inhibition at 30 mg/kg, po QD administered via gavage for 28 days and measured twice weekly relative to control | Homo sapiens | 3 | ALA4819022 | organism-based format | Scientific Literature | |
| 12. | ALA4820492 | F | In vivo antagonist activity at AR in peripubertal castrated male Sprague-Dawley rat assessed as inhibition of testosterone propionate-induced increase in paired cowper's gland weight at 30 mg/kg, po QD for 10 days measured 24 hrs post last dose by Hershberger's assay | Rattus norvegicus | 9 | ALA4819022 | organism-based format | Scientific Literature | |
| 13. | ALA4820493 | F | In vivo antagonist activity at AR in peripubertal castrated male Sprague-Dawley rat assessed as inhibition of testosterone propionate-induced increase in seminal vesicle with fluid and coagulating gland weight at 30 mg/kg, po QD for 10 days measured 24 hrs post last dose by Hershberger's assay | Rattus norvegicus | 9 | ALA4819022 | organism-based format | Scientific Literature | |
| 14. | ALA4820494 | F | In vivo antagonist activity at AR in peripubertal castrated male Sprague-Dawley rat assessed as inhibition of testosterone propionate-induced increase in glans penis weight at 30 mg/kg, po QD for 10 days measured 24 hrs post last dose by Hershberger's assay | Rattus norvegicus | 9 | ALA4819022 | organism-based format | Scientific Literature | |
| 15. | ALA4820495 | F | In vivo antagonist activity at AR in peripubertal castrated male Sprague-Dawley rat assessed as inhibition of testosterone propionate-induced increase in ventral prostate weight at 30 mg/kg, po QD for 10 days measured 24 hrs post last dose by Hershberger's assay | Rattus norvegicus | 9 | ALA4819022 | organism-based format | Scientific Literature | |
| 16. | ALA4820496 | F | In vivo antagonist activity at AR in peripubertal castrated male Sprague-Dawley rat assessed as inhibition of testosterone propionate-induced increase in levator anti-bulbocavernosus complex weight at 30 mg/kg, po QD for 10 days measured 24 hrs post last dose by Hershberger's assay | Rattus norvegicus | 9 | ALA4819022 | organism-based format | Scientific Literature | |
| 17. | ALA4820497 | A | Drug concentration in SCID mouse plasma xenografted with human LNCaP cells harboring AR F877L mutant at 30 mg/kg, po QD administered via gavage for 28 days | Mus musculus | 2 | ALA4819022 | organism-based format | Scientific Literature | |
| 18. | ALA4820512 | A | Drug metabolism in dog liver microsomes assessed as unchanged parent compound at 10 uM incubated for 60 mins in presence of glutathione by LC-MS/MS analysis | Canis lupus familiaris | 4 | ALA4819022 | microsome format | Scientific Literature | |
| 19. | ALA4820513 | A | Drug metabolism in dog liver microsomes assessed as unchanged parent compound at 10 uM incubated for 60 mins in presence of glutathione and NADPH by LC-MS/MS analysis | Canis lupus familiaris | 4 | ALA4819022 | microsome format | Scientific Literature | |
| 20. | ALA4820514 | A | Drug metabolism in dog liver microsomes assessed as oxidation of parent compound causing metabolite formation at 10 uM incubated for 60 mins in presence of glutathione and NADPH by LC-MS/MS analysis | Canis lupus familiaris | 4 | ALA4819022 | microsome format | Scientific Literature |
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